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Articles by Y. Saidu
Total Records ( 3 ) for Y. Saidu
  S.A. Habibullah , L.S. Bilbis , M.J. Ladan , O.P. Ajagbonna and Y. Saidu
  Reducing cholesterol content of table egg may be important in curbing the risks of atherosclerosis. In this study, forty, (32 week old) Shika Brown laying hens were randomly distributed into five groups to investigate the effect of aqueous extract of Hibiscus sabdariffa calyces on serum lipid profile and egg yolk cholesterol. Groups 2 - 5 received 1, 2, 4 or 8 g L-1 solution of the extract. Group 1 (control) received tap water. All the animals were fed ad libitum with layers mash for twelve weeks. Blood samples and eggs were collected after every three weeks and sera and egg yolk were analyzed for total cholesterol, triglycerides (TAG), high-density lipoprotein cholesterol (HDL-C) and egg yolk cholesterol respectively. Hibiscus sabdariffa extract caused a significant (p<0.05) non dose dependent increase in serum total cholesterol and egg yolk cholesterol but significant (p<0.05) dose-dependent decrease in serum TAG and HDL-C content. No strong correlation (0.2273) was found between serum and yolk total cholesterol. These results suggest that aqueous extract of Hibiscus sabdariffa may possess hypotriglyceridemic effect in Shika Brown laying hens but caused increase in serum and egg yolk cholesterol.
  S.W. Hassan , M. Lawal , B.Y. Muhammad , R.A. Umar , L.S. Bilbis and Y. Saidu
  The anthraquinone glycosides composition and toxicity studies of isolated anthraquinone glycosides and aqueous ethanol stem bark extracts of Ficus sycomorus on rat liver and kidney functions were conducted. The yield of anthraquinone glycosides in 40 g powdered stem bark extract was 16.0% (w/v). Liver and renal indices were significantly (p<0.05) changed at higher doses of 617.86, 988.57 (anthraqiunone glycosides), 767.80 and 1228.60 mg kg-1 body weight (aqueous ethanol extract). Dose dependant decrease in weight (p<0.05) was observed in the rats administered higher doses of the aqueous ethanol and anthraquinone glycosides extracts. The results suggest that extracts of Ficus sycomorus cause adverse effects to liver and kidney at higher doses.
  Y. Saidu , M. Lawal , S.A. Isezuo , R.A. Shehu , D.M. Sahabi and L.S. Bilbis
  This research studied the hypoglycaemic effect of aqueous leaf extract of Albizzia chevalieri in alloxan-induced diabetic albino rats, using activity-guided fractionation. Preliminary elucidation of the mechanism of hypoglycaemic activity was also studied. The crude aqueous leaf extract of the plant (100 mg kg-1 body weight) reduced blood glucose levels of both the diabetic and normal rats by about 30%. The hypoglycaemic agent(s) were fractionated in the hexane fraction of the aqueous extract and partitioned in the second elution fraction (H2) by column chromatography. Thin layer chromatography of H2 gave a single spot with water as the mobile phase. The preliminary results of the mechanism of action indicated that the extract did not affect the in vivo digestion of carbohydrate or intestinal absorption of glucose. It however caused significant (p<0.05) increase in the hepatic and extrahepatic glycogen store. Phytochemical screening of the crude extract indicated the presence of saponins, flavonoids, tannins, terpenes, steroids, balsams, glycosides and alkaloids. UV/visible spectral studies of H2 indicated a λmax of 320 nm. These results suggest that the hypoglycaemic effect of the extract is as a result of induction of glycogenesis.
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