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Articles by Y. Nakamura
Total Records ( 4 ) for Y. Nakamura
  K Noda , C Arai and Y. Nakamura
 

The purpose of this study was to assess the rate of root resorption in relation to different magnitudes of continuous force during experimental tooth movement using nickel–titanium (NiTi) alloy wire. Four force magnitudes of 0.8, 1.6, 4, and 8 g were applied to the upper first molars of 75 male Wistar rats (300–320 g, 10-week-old) for 1, 7, 14, 21, and 28 days and compared with a control group without an orthodontic appliance. Light microscopic images of the compressed periodontal ligament (PDL) were processed by computer, and the ratio of the root resorption lacuna length to root surface length without the lacuna was analysed and statistically compared using Tukey–Kramer multiple comparison honestly significant difference test.

The experimental groups with 4 and 8 g force showed undermining bone resorption with degenerating tissue and marked root resorption, the 1.6 g group showed only root resorption, while the 0.8 g group was similar to the control. Comparison of the ratios showed that the 0.8 g group was similar to the control with no significant difference. The ratio on day 28 in the 1.6 g group was larger than that in the 0.8 g and control groups, while on days 14, 21, and 28, the ratios in the 4 and 8 g groups were larger than those in the control (P < 0.01); these two experimental groups showed the same significant differences.

It is suggested that significant root resorption occurs when the force magnitude exceeds 1.6 g in the rat upper first molar during tipping tooth movement by continuous force, and the amount of root resorption increases with serial force magnitudes from 0.8 to 4 g.

  H Akaza , K Kawai , T Tsukamoto , T Fujioka , Y Tomita , T Kitamura , S Ozono , T Miki , S Naito , H Zembutsu and Y. Nakamura
  Objective

In our previous study, a combination therapy of interleukin-2 and interferon- was found to be more effective than monotherapy, especially for lung metastasis. In order to determine the genetic markers of those who positively responded, a multi-institutional open study was conducted on the patients with lung metastasis. In this paper, the clinical response to our combination therapy is reported.

Methods

Untreated patients with lung metastasis were enrolled in this study. Patients received interleukin-2 (0.7 x 106 U/day) and interferon- (6 x 106 IU/day): interleukin-2, 5 days a week and interferon-, 3 days a week for the first 8 weeks, and then both interleukin-2 and interferon-, 2 or 3 days a week for 16 additional weeks.

Results

Forty-two patients were able to be evaluated for response. The overall positive response rate was 35.7% (15 of 42) including 2 patients with complete response. Progression-free patients were observed more frequently in patients with lung metastasis only (80.6%) than those with lung plus other organ metastasis (54.5%). Tumor shrinkage was observed in 81.0% (34 of 42) of patients. Progression-free survival rate at 200 days was 63.6%. Toxicities observed were primarily flu-like symptoms due to the cytokines and were typical of those observed with each single agent.

Conclusions

Combination therapy of interleukin-2 and interferon- was confirmed to be effective for renal cell carcinoma patients with lung metastasis. Identification of genetic markers is now ongoing with the tissue samples from this trial.

  T Sawada , P. B Francisco , S Aihara , Y Utsumi , M Yoshida , Y Oyama , M Tsuzuki , H Satoh and Y. Nakamura
 

In monocots, starch branching enzyme II (BEII) was functionally differentiated into BEIIa and BEIIb after separation from the dicots, and in cereals BEIIb plays a distinct role in amylopectin biosynthesis in the endosperm. The present study was conducted to examine to what extent a green algal BEII has an overlapping function with BEIIb in starch biosynthesis by introducing the Chlorella BEII gene into an amylose-extender (ae) mutant of rice. Chlorella BEII was found to complement the contribution of the rice endosperm BEIIb to the structures of amylopectin and starch granules because these mutated phenotypes were recovered almost completely to those of the wild type by the expression of Chlorella BEII. When the recombinant BE enzymes were incubated with the rice ae amylopectin, the branching pattern of Chlorella BEII was much more similar to that of rice BEIIb rather than rice BEIIa. Detailed analyses of BE reaction products suggests that BEIIb and Chlorella BEII only transfer chains with a degree of polymerization (DP) of 6 and 7, whereas BEIIa preferably transfers short chains with a DP of about 6–11. These results show that the Chlorella BEII is functionally similar to rice BEIIb rather than BEIIa.

 
 
 
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