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Articles by Y. Ma
Total Records ( 2 ) for Y. Ma
  D. Dabelea , Y. Ma , W. C. Knowler , S. Marcovina , C. D. Saudek , R. Arakaki , N. H. White , S. E. Kahn , T. J. Orchard , R. Goldberg , J. Palmer and R. F. Hamman


To determine if the presence of diabetes autoantibodies predicts the development of diabetes among participants in the Diabetes Prevention Program.


A total of 3050 participants were randomized into three treatment groups: intensive lifestyle intervention, metformin and placebo. Glutamic acid decarboxylase (GAD) 65 autoantibodies and insulinoma-associated-2 autoantibodies were measured at baseline and participants were followed for 3.2 years for the development of diabetes.


The overall prevalence of GAD autoantibodies was 4.0%, and it varied across racial/ethnic groups from 2.4% among Asian-Pacific Islanders to 7.0% among non-Hispanic black people. There were no significant differences in BMI or metabolic variables (glucose, insulin, HbA1c, estimated insulin resistance, corrected insulin response) stratified by baseline GAD antibody status. GAD autoantibody positivity did not predict diabetes overall (adjusted hazard ratio 0.98; 95% CI 0.56-1.73) or in any of the three treatment groups. Insulinoma-associated-2 autoantibodies were positive in only one participant (0.033%).


These data suggest that ‘diabetes autoimmunity’, as reflected by GAD antibodies and insulinoma-associated-2 autoantibodies, in middle-aged individuals at risk for diabetes is not a clinically relevant risk factor for progression to diabetes.

  Y. Ma , R.R. Li , F. Hou , Y.H. Zhang , H. Chen , S.Z. Xu , N. Cheng and W.S. Liu
  Angiopoietin-like 4 (ANGPTL4), a member of the angiopoietin-like gene family, encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain which is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. ANGPTL4 is a serum hormone directly involved in regulating angiogenesis, lipid metabolism, glucose metabolism, cancer and metabolic diseases. In this study, Radiation Hybrid (RH) cloning board technique, PCR-SSCP and DNA sequencing methods were employed to map bovine ANGPTL4 gene and examine the single nucleotide polymorphisms (SNPs) at the 3'UTR of this gene in 281 cattle from seven breeds. Here, the bovine ANGPTL4 gene was located between the framework marker CA006 and DIK4204 on BTA7 with a map distance of 2.33 cR to the former and an interval of 8.54 cR to the latter. A novel mutation (NC_007305.3: g.C6640T) was revealed which constructed three genotypes (CC, CT and TT). This locus proved to be significantly associated with Average Daily Gain (ADG), Rib-eye Area (REA), Intramuscular Fat (IMF) (p<0.05) and Beef Performance Index (BPI) (p<0.01) in the analyzed populations. Meanwhile, individuals with genotype TT were significantly higher than those with CC in BPI, ADG and REA while it was reversed for genotype TT and CC in the IMF which proved that bovine ANGPTL4 gene had a positive effect on production traits. Hence, genotype TT and CC could be regarded as molecular markers for BPI, ADG and REA and IMF, respectively.
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