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Articles by Y. Luo
Total Records ( 2 ) for Y. Luo
  L. Zhang , Y. Luo , J. Hu , J. Wang , X. Liu and H. Pan
  CAPNS1 also known as CAPN4, encodes the small subunit of CAPN1 and CAPN2 which is required to maintain stability and activity of both calpains. But to date polymorphism of yak CAPNS1 has not been reported. In this study, variation in the exon 6-intron 6 region of CAPNS1 was investigated in 1059 yaks and Chinese cattle by Polymerase Chain Reaction-Single Strand Conrmational Polymorphism (PCR-SSCP). Five PCR-SSCP patterns representing five allelic variations and containing four Single Nucleotide Polymorphisms (SNPs) in intron 6 were observed. Allele B was the most common allele with a frequency of 48.12% in yak and 93.29% in Chinese cattle whereas allele A and C were only in yak as well as allele D and E were rare (0.42 and 0.16%, respectively) and only in Chinese cattle. These results indicate that yak and cattle CAPNS1 is polymorphic and suggest further analysis is required to see if the variation detected affects their meat quality.
  F. X Yu , S. R Goh , R. P Dai and Y. Luo
 

Eukaryotic cells sense extracellular glucose concentrations via diverse mechanisms to regulate the expression of genes involved in metabolic control. One such example is the tight correlation between the expression of thioredoxin-interacting protein (Txnip) and extracellular glucose levels. In this report, we show that the transcription of the Txnip gene is induced by adenosine-containing molecules, of which an intact adenosine moiety is necessary and sufficient. Txnip promoter contains a carbohydrate response element, which mediates the induction of Txnip expression by these molecules in a glucose-dependent manner. Max-like protein X and MondoA are transcription factors previously shown to stimulate glucose-dependent Txnip expression and are shown here to convey stimulatory signals from extracellular adenosine-containing molecules to the Txnip promoter. The regulatory role of these molecules may be exerted via amplifying glucose signaling. Hence, this revelation may pave the way for interventions aimed toward metabolic disorders resulting from abnormal glucose homeostasis.

 
 
 
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