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Articles by Y. Lu
Total Records ( 9 ) for Y. Lu
  H Li and Y. Lu

Phenotypic inheritance induced by RNA has been documented in mouse and Caenorhabditis elegans. Here we report a similar inheritance in Drosophila. Mutant phenotypes of eye defects and antenna duplication generated from the crossing of one RNA interference (RNAi) transgenic line harboring one hairpin RNA transgene with a GAL4 driver line were inherited independently of the GAL4 driver. Hairpin RNA injection experiments demonstrated that the hairpin RNA could induce heritable mutant-like phenotypes on the eye and antenna. The penetrance of mutant phenotypes was reduced when the mutants were crossed to ago1 and piwi mutants. Our data suggest that hairpin RNA can induce phenotypic inheritance in Drosophila.

  Y Lou , Q Peng , B Nolan , G. C Wagner and Y. Lu

Treatment of p53(–/–) mice orally with caffeine, voluntary exercise or their combination for 2 weeks prior to a single irradiation with UVB (i) decreased the weight of the epididymal fat pads by 22, 40 and 56%, (ii) decreased the thickness of the dermal fat layer by 10, 26 and 42%, (iii) increased the number of apoptotic sunburn cells by 29, 100 and 489%, (iv) increased the number of caspase-3-positive cells by 33, 117 and 667% and (v) increased the number of mitotic cells with cyclin B1-positive staining by 40, 210 and 510%, respectively. Pearson's correlation coefficient indicated a statistically significant inverse relationship between the level of tissue fat and the number of mitotic cells with cyclin B1 in p53(–/–) mice but not in p53(+/+) littermates. Western blot analysis indicated that treatment of p53(–/–) mice with caffeine together with exercise increased the level of cyclin B1 significantly more than in p53(+/+) mice. p53(–/–) mice, but not p53(+/+) mice, treated with caffeine during exercise exhibited a dramatic decrease in the level of survivin. Our results suggest that voluntary exercise in combination with oral caffeine may exert a synergistic increase in UVB-induced apoptosis and that tissue fat may be a more important modulator of apoptosis and carcinogenesis in p53-deficient mice than in p53-normal mice. The stimulatory effects on apoptosis in p53(–/–) mice by the combination treatment might be associated with increased levels of cyclin B1 and decreased levels of survivin.

  F. Bragg , L. Li , M. Smith , Y. Guo , Y. Chen , I. Millwood , Z. Bian , R. Walters , J. Chen , L. Yang , R. Collins , R. Peto , Y. Lu , B. Yu , X. Xie , Y. Lei , G. Luo and Z. Chen


To examine the relationship of self-reported diabetes, and of random blood glucose levels among individuals without known diabetes, with the prevalence of cardiovascular disease in Chinese adults.


We examined cross-sectional data from the China Kadoorie Biobank of 0.5 million people aged 30-79 years recruited from 10 diverse regions of China in the period 2004-2008. Logistic regression was used to estimate the odds ratios of prevalent cardiovascular disease associated with self-reported diabetes, and with measured random blood glucose levels among participants with no history of diabetes, adjusting simultaneously for age, sex, area, education, smoking, alcohol, blood pressure and physical activity.


A total of 3.2% of participants had self-reported diabetes (men 2.9%; women 3.3%) and 2.8% had screen-detected diabetes (men 2.6%; women 2.8%), i.e. they had no self-reported history of diabetes but a blood glucose level suggestive of a diagnosis of diabetes. Compared with individuals without a history of diabetes, the odds ratios associated with self-reported diabetes were 2.18 (95% CI 2.06-2.30) and 1.88 (95% CI 1.75-2.01) for prevalent ischaemic heart disease and stroke/transient ischaemic attack, respectively. Among participants without self-reported diabetes there was a positive association between random blood glucose and ischaemic heart disease and stroke/transient ischaemic attack prevalence (P for trend <0.0001). Below the diabetic threshold (<11.1 mmol/l) each additional 1 mmol/l of random blood glucose was associated with 4% (95% CI 2-5%) and 5% (95% CI 3-7%) higher odds of prevalent ischaemic heart disease and stroke/transient ischaemic attack, respectively.


In this adult Chinese population, self-reported diabetes was associated with a doubling of the odds of prevalent cardiovascular disease. Below the threshold for diabetes there was still a modest, positive association between random blood glucose and prevalent cardiovascular disease.

  J. Chen , Y. Lu and X. Xie
  This study proposes a testing approach of component security based on dynamic fault tree and then specifies some related definitions of fault tree, fault injection model and attack pattern. A testing algorithm of component security based on dynamic fault tree and test-case generating approach are also proposed. The proposed testing approach generates fault injection cases which can trigger component vulnerabilities in maximum probability based on fault tree. At the same time, the fault tree can be improved according to the testing results after injecting faults. The proposed approach was implemented based on research projects CSTS (Component Security Testing System). The experimental results show that the approach is effective and can trigger lots of component exceptions by using fewer test-cases.
  C. Ju , B. Xu , Y. Lu , X.J. Mo , T. Zhang , S.B Chen , F. Liu , S.J. Cui , W. Liu , J.H. Chen , Z. Feng , J.X. Peng and W. Hu
  Schistosomiasis ranks as the second most serious parasitic disease worldwide after malaria. More than 250 million people are infected with schistosomes in the tropics or subtropics. The treatment and control of schistosomiasis which is a major neglected tropical parasitic disease, depends almost exclusively on chemotherapy with Praziquantel (PZQ). Current serologic diagnostic assays have shown that schistosome specific antibodies in human serum may remain for at least 1 year after cure. Repeated administration of PZQ for a long time might induce drug resistance to the parasite which is a big challenge for strategizing for the prevention and control of schistosomiasis. As schistosome eggs represent the most pathogenic form causing the disease, it is essential to determine if and how the level of antibodies against schistosome Soluble Egg Antigens (SEA) is affected by PZQ treatment. In this study, researchers carried out an immunomic analysis to profile Schistosoma japonicum SEA reacting with pooled human serum samples of pre and post treatment with PZQ by two dimensional electrophoresis combined with Western blotting. A total of 67 protein spots that were serologically recognized by serum samples were successfully subjected to mass spectrometric analysis. Of them, 37 different characterized proteins were successfully identified. Furthermore, of 67 protein spots, the reactivity of 49 protein spots to sera was reduced 20 weeks after PZQ treatment whereas only 5 spots showed increases in the intensity of recognition by post treatment sera. The present study suggested that chemotherapy with PZQ mainly affects the intensity of serological recognition of S. japonicum SEA. The immunomic proteins that were identified may facilitate a better understanding of the egg induced pathogenesis of schistosomiasis and host-parasite interplay and may provide potential targets for the diagnosis and evaluation of treatment for the disease as well.
  L. Ai , M.X. Chen , S.H. Chen , Y.N. Zhang , H. Li , Y.C. Cai , Y. Lu , L.G. Tian , X.N. Zhou and J.X. Chen
  MicroRNAs (miRNAs) are small non-coding RNA which generate from large hairpin precursors and play important role on post-transcriptional regulators of target genes. Although, many individual miRNAs have recently been extensively studied, there has been very little research on miRNA transcriptomes in trematode. By the method of using high throughput Solexa sequencing technology, 11.02 million clean reads have been obtained of Paragonimus westermani. Among the clean reads, 1.14 million ones (10.37%) were perfectly mapped onto the S. japonicum genome which included 20,322 (0.69%) unique sequences. A number of 9,492,613 (86.17%) reads had no match with public databases and marked as un-annotated RNAs. Nucleotide bias analysis found that the known miRNAs showed high bias and the guanine was the dominant nucleotide, particularly at the 2nd and 23rd positions which were almost at the beginning and end of conserved miRNAs. Three novel miRNA corresponding to 18 precursors were predicted. To the knowledge, this is the first report of miRNA profiles in P. westermani which will contribute to better understanding of the complex biology of this zoonotic parasite. The reported data of P. westermani miRNAs should provide valuable references for miRNA studies of closed related zoonotic trematode.
  F.W. Li , Y. Lu , Q.X. Lei , Y. Zhou , H.X. Han , G.M. Li , B. Wu , D.G. Cao and S.B. Wang
  In order to find the relationship between immune traits and the Major Histocompatibility Complex B-F (MHC B-F) gene, an immune traits model was established in Wenshang Barred Chicken (LH), Laiwu Black Chicken (LWH) and Jining Bairi Chicken (BR). PCR-SSCP and sequencing methods were used to identified haplotypes in these three Shandong indigenous chickens. As a result, 53 (LH), 52 (LWH) and 54 (BR) Single Nucleotide Polymorphisms (SNPs) were found in the 264 bp of exon 2 in chicken MHC B-F gene. The least square analysis showed that 2, 2, 3 SNPs were respectively found significant associations with antibody responses to H5, H9 and ND in LH chickens; 1, 3 and 3 SNPs were respectively found significant associations with antibody responses to H5, H9 and ND in LWH chickens but none with SRBC. In BR chickens, there was association with responses to H5 (2 SNPs), H9 (3 SNPs), ND (3 SNPs) and SRBC (3 SNPs). These results indicate that the genomic region bearing exon 2 of the MHC B-F gene has significant effects on antibody responses to SRBC and vaccination against AI and ND.
  D.G. Cao , Y. Zhou , Q.X. Lei , H.X. Han , F.W. Li , G.M. Li , Y. Lu , B. Wu and Z.L. Wang
  Chicken Very Low Density Lipoprotein Receptor (VLDLR) is a physiological candidate gene for reproductive traits. The objective of the current research was to investigate the association of VLDLR Single Nucleotide Polymorphisms (SNPs) and the reproductive traits in a Chinese Indigenous chicken breed (Wenshang Luhua chicken). A total of 528 individuals were genotyped with PCR-Restriction Fragment Length Polymorphism (PCR-RFLP). As a result, an A→G mutation on exon 6 (A12321G) and an A→G mutation on intron 17 (A13876G) were identified. In locus 12321, genotypes have significantly effect on Egg Weight at 300 days (EW) and the chickens harboring genotype A2A2 had significantly higher EW (p<0.05) than that of A1A1 chickens. Also the Egg Weight at First Egg (EWFE) and Egg Production at 300 days (EP) values of A2A2 chickens were higher than A1A1 chickens and A2A2 chickens had lower Living Weight at First Egg (LWFE), Living Weight at 300 days (LW) and Age at First Egg (AFE) than A1A1 chickens. In locus 13876, genotypes had significantly effect on EW (p<0.05). The EW values of B2B2 chickens were significantly higher than B1B1 chickens (p<0.05). For LWFE, LW and EP, B2B2 chickens were superior to B1B1 chickens but no significant difference between them (p>0.05). Four diplotypes were constructed on the two SNPs. Significantly dominant effects of diplotypes H1H1 were observed for traits EW whereas H4H4 had a negative effect on it. Also for EWFE, LWFE, LW and EP, the H1H1 chickens were superior to H4H4 chickens it maybe tell that H1H1 is an advantaged diplotype for chicken reproductive traits.
  H. Sheng , Y. Lu and H. Chen
  The purpose of this study was to investigate ocular complications among a group of patients on long-term, high-dose immunosuppression and corticosteroids for the maintenance of orthotopic heart transplants. Additionally, we provided information pertinent for the early diagnosis and treatment of eye diseases. In this study, we retrospectively assessed the clinical data of 138 patients with orthotopic heart transplantations from May 2000 to October 2005, including assessment of ophthalmic symptoms and signs, as well as the general condition, treatment, and prognosis. Of 138 transplant recipients examined (276 eyes), 47 eyes (17.0%) showed ocular surface diseases. Sixty-four (23.2%) had a posterior subcapsular cataract, and 16 (5.8%) corticosteroid glaucoma. Fifteen (5.6%) had ocular fundus diseases. Various ocular complications related to immunosuppression and corticosteroids appear among heart transplant patients. Cardiac surgeons and ophthalmologists must closely evaluate ocular symptoms in the posttransplantation period.
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