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Articles by Y. He
Total Records ( 6 ) for Y. He
  T Holopainen , H Huang , C Chen , K. E Kim , L Zhang , F Zhou , W Han , C Li , J Yu , J Wu , G. Y Koh , K Alitalo and Y. He

The angiopoietin-1 (Ang1)/Tie2 signaling pathway is known to play an important role in the regulation of vascular maturation and maintenance of vessel integrity. In this study, we have investigated the effect of systemic Tie2 activation or inhibition on tumor growth and metastasis. We found that treatment with Ang1 delivered via an adenoviral vector promoted s.c. implanted tumor metastasis to the lungs. Ang1 treatment did not significantly increase vascular density in the tumors but induced enlargement of blood vessels in both the tumor and normal tissues, which increased tumor cell dissemination into the blood circulation. Ang1 also enhanced the formation of metastatic foci in the lungs when tumor cells were injected into the circulation via the tail vein. The effect of Ang1 on metastasis was validated by a simultaneous treatment with a soluble form of Tie2 (sTie2), which led to the suppression of Ang1-induced increase of tumor metastasis. Furthermore, using a highly metastatic tumor model, we confirmed that systemic treatment with sTie2 suppressed tumor metastasis to the lungs and lymph nodes, whereas tumor-associated angiogenesis and lymphangiogenesis were not significantly affected. This suggests that the Ang1/Tie2 signals contribute to tumor progression by increasing vascular entry and exit of tumor cells to facilitate tumor dissemination and establishment of metastases. [Cancer Res 2009;69(11):4656–64]

  Y. He

Missing data are a pervasive problem in health investigations. We describe some background of missing data analysis and criticize ad hoc methods that are prone to serious problems. We then focus on multiple imputation, in which missing cases are first filled in by several sets of plausible values to create multiple completed datasets, then standard complete-data procedures are applied to each completed dataset, and finally the multiple sets of results are combined to yield a single inference. We introduce the basic concepts and general methodology and provide some guidance for application. For illustration, we use a study assessing the effect of cardiovascular diseases on hospice discussion for late stage lung cancer patients.

  M.J. Xu , Y. He , R. Liang , D.H. Zhou , R.Q. Lin , C.C. Yin , X.H. He , M. Liang and X.Q. Zhu
  The present investigation aimed to examine the prevalence of Chlamydia infection in pigs in Guangdong Province, Southern China. Between March 2008 and May 2009, a total of 1,017 serum samples were collected from 15 intensive farms, which are distributed in 12 administrative cities of Guangdong Province and assayed for Chlamydia antibodies by Indirect Hemagglutination Assay (IHA). The results showed that almost all of the investigated farms showed seroprevalence (93.33%, 14/15). The average seroprevalence of pigs with Chlamydia antibodies was 30.78% (ranged between 0-88%) with breeding boars having the highest prevalence (63.38%, 45/71), which was followed by breeding sows (41.10%, 60/146) and fattening pigs (36.25%, 29/80). These results indicated that prevalence of Chlamydia infection in pigs from intensive farms in Southern China is high, therefore integrated and improved control strategies and measures should be implemented to prevent and control Chlamydia infection in pigs.
  G.H. Peng , Z.G. Yuan , D.H. Zhou , X.H. He , C. Yan , C.C. Yin , Y. He , R.Q. Lin , H.Q. Song and X.Q. Zhu
  Toxoplasma gondii infects nearly one third of the total population of the world, as well as warm blooded animals causing serious public health problems and economic losses in the world. Micronemes plays a key role in the invasion process of T. gondii which are used for host cell recognition, binding and motility. In this research, the researchers examined sequence variation in the microneme protein 4 (MIC4) gene sequences of 12 T. gondii isolates and reference strains from different hosts and geographical locations, then constructed the DNA vaccine expressing MIC 4 of T. gondii evaluated its immune response induced in Kunming mice. The results demonstrated that sequence variation in MIC 4 among different T. gondii isolates was low, which is a useful feature as a vaccine candidate. Immunization of mice with pVAX-MIC4 induced strong immune responses in mice as shown by significant lymphocyte proliferation, cytokine production and antibody responses as well as increased survival time of the immunized mice after challenge with tachyzoites of the virulent T. gondii RH strain, demonstrating that T. gondii MIC4 is a potential vaccine candidate against toxoplasmosis.
  Y. He

The timing of floral transition is critical to reproductive success in angiosperms and is genetically controlled by a network of flowering genes. In Arabidopsis, expression of certain flowering genes is regulated by various chromatin modifications, among which are two central regulators of flowering, namely FLOWERING LOCUS C (FLC) and FLOWERING LOCUS T (FT). Recent studies have revealed that a number of chromatin-modifying components are involved in activation or repression of FLC expression. Activation of FLC expression is associated with various ‘active’ chromatin modifications including acetylation of core histone tails, histone H3 lysine-4 (H3K4) methylation, H2B monoubiquitination, H3 lysine-36 (H3K36) di- and tri-methylation and deposition of the histone variant H2A.Z, whereas various ‘repressive’ histone modifications are associated with FLC repression, including histone deacetylation, H3K4 demethylation, histone H3 lysine-9 (H3K9) and H3 lysine-27 (H3K27) methylation, and histone arginine methylation. In addition, recent studies have revealed that Polycomb group gene-mediated transcriptional-silencing mechanism not only represses FLC expression, but also directly represses FT expression. Regulation of FLC expression provides a paradigm for control of the expression of other developmental genes in plants through chromatin mechanisms.

  Y. Wang , Y. He , H. Zhang , J. Schroder , C. Li and D. Zhou
  Phosphate mobilization by organic acids has been shown to be soil type dependent and controlled by the soil`s intrinsic P status. The objective of this study was to evaluate the capacity and mechanisms of three organic acids in the mobilization of phosphate from an upland clay loam Ultisol that had received different long-term fertilizer treatments. Soil samples were incubated at 25 ± 1°C and 40% moisture content for 3 wk with citric, tartaric, or oxalic acid at 1.0 mmol kg–1 of soil. Soil pH, inorganic P fractions, and plant-available P (Olsen P) were analyzed after incubation. The results indicated that Olsen P and the loosely bound P extracted with 1.0 mol L–1 NH4Cl (NH4Cl-P) were significantly increased by the treatment of the three organic acids, and Fe phosphate (Fe-P), occluded phosphate (Oc-P), and Ca phosphate (Ca-P) were mobilized and released to various degrees as well. The order of increased mobilization of P by the organic acids was citric acid > tartaric acid > oxalic acid. These three organic acids have the potential to increase the availability of P in soil but need to be evaluated at the field scale.
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