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Articles by Y. T Chen
Total Records ( 2 ) for Y. T Chen
  M. C Wu , K. S Cheng , Y. T Chen , J. K Liu and W. H. Ting

The aims of this study were to reconstruct a three-dimensional (3D) model, to provide a 3D analysis using biplanar cephalograms [postero-anterior (PA) and lateral] with orthogonal projection, and to compare the differences between the 3D and two-dimensional (2D) analyses. The procedures were as follows: (1) to identify landmarks from a dry skull and to construct the norms for the spatial information of the skull from the 3D reconstruction using computerized tomography (CT); (2) to reconstruct a 3D model using biplanar cephalograms (PA and lateral); and (3) to compare the differences between the 2D and 3D analyses. Fifteen clearly visible landmarks identified on both films were used in this study.

By comparing the data from the CT and the biplanar cephalograms, it was found that the accuracy for the 3D linear measurements from biplanar cephalograms was 98.9 per cent. However, the accuracy for the linear measurements from 2D and CT data was only 89.2 per cent. If the measurement of gonion (Go) to menton (Me) was excluded, the accuracy for the linear measurements from 2D and CT data was 95.1 per cent. When using a t-test to compare the linear distances of 2D-CT and 3D-CT data (Go to Me excluded), the difference was statistically significant (P < 0.05). The findings indicate that biplanar cephalograms with orthogonal projection are able to provide a 3D analysis that is more accurate than 2D analysis.

  C. C Tsai , C. L Lin , T. L Wang , A. C Chou , M. Y Chou , C. H Lee , I W Peng , J. H Liao , Y. T Chen and C. Y. Pan

Vesicle recycling is vital for maintaining membrane homeostasis and neurotransmitter release. Multiple pathways for retrieving vesicles fused to the plasma membrane have been reported in neuroendocrine cells. Dynasore, a dynamin GTPase inhibitor, has been shown to specifically inhibit endocytosis and vesicle recycling in nerve terminals. To characterize its effects in modulating vesicle recycling and repetitive exocytosis, changes in the whole cell membrane capacitance of bovine chromaffin cells were recorded in the perforated-patch configuration. Constitutive endocytosis was blocked by dynasore treatment, as shown by an increase in membrane capacitance. The membrane capacitance was increased during strong depolarizations and declined within 30 s to a value lower than the prestimulus level. The amplitude, but not the time constant, of the rapid exponential decay was significantly decreased by dynasore treatment. Although the maximal increase in capacitance induced by stimulation was significantly increased by dynasore treatment, the intercepts at time 0 of the curve fitted to the decay phase were all ~110% of the membrane capacitance before stimulation, regardless of the dynasore concentration used. Membrane depolarization caused clathrin aggregation and F-actin continuity disruption at the cell boundary, whereas dynasore treatment induced clathrin aggregation without affecting F-actin continuity. The number of invagination pits on the surface of the plasma membrane determined using atomic force microscopy was increased and the pore was wider in dynasore-treated cells. Our data indicate that dynamin-mediated endocytosis is the main pathway responsible for rapid compensatory endocytosis.

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