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Articles by Y. Kodandhapani
Total Records ( 1 ) for Y. Kodandhapani
  R. Hemalatha , Y. Kodandhapani and N. Balakrishna
  Animal studies have shown that in addition to generalized effects on immune function, zinc and vitamin A can influence Th1 and Th2 cytokine responses and thus have a profound impact on the outcome of infectious illnesses. However, vitamin A supplementation studies on children with respiratory infection are controversial. It is hypothesized that vitamin A may modulate the Th1 and Th2 bias and alter the course of respiratory infection. Therefore in this study, the micronutrient status of children during acute respiratory infection and their association with local cytokine response was determined. In addition, to study the impact of large dose vitamin A on Th1 and Th2 modulation, cytokine response was studied after oral administration of 2 lacs IU of vitamin A in normal children. Seventy two children aged 10 months to 3 years with ARI were recruited from Niloufer Hospital, Hyderabad. Cytokine response, hemoglobin status, serum zinc and vitamin A levels were determined in these children with vitamin A deficiency and compared with thirty apparently normal children of similar age group and socioeconomic status. In ten normal children, cytokine response was studied after oral administration of 2 lakhs IU of vitamin A. Correlation coefficient on log-transformed data showed a significant (p<0.05) inverse association of serum vitamin A and nasopharyngeal aspirate IL2 in children with acute respiratory infection. Other nutritional parameters (weight for age, hemoglobin and zinc) showed no correlation with nasopharyngeal aspirate IL2. Children supplemented with vitamin A showed a significant (p<0.05; paired t test) decrease in IL2 response from peripheral blood mononuclear cell culture supernatant compared to the baseline concentration. The study shows that vitamin A modulates TH1 response, which may be responsible for the increased morbidity seen when children with ARI are supplemented with Vitamin A.
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