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Articles by Y. C. Liu
Total Records ( 2 ) for Y. C. Liu
  C. Y Lin , Y. C Tseng and Y. C. Liu

An important issue of wireless sensor networks is object tracking, where the key steps include event detection, target classification, location estimation and location management. The main theme of this paper is location management. Because imprecision is an inherent property in object-tracking sensor networks, this paper focuses on the scenarios where users can tolerate a certain degree of imprecision in their query results. We intend to develop a location management scheme that can achieve two goals. First, multiple precision levels are provided. Second, the query cost is proportional to the precision level. To achieve these two goals, we propose a tree-based imprecision-tolerant location management scheme that includes three major components: (1) update and query mechanisms that can support imprecision-tolerant queries, (2) the approach to taking the statistics of imprecision-tolerant queries and (3) a tree construction algorithm that can reduce the query cost and minimize the increment of update cost. Performance evaluations are conducted through simulations to verify the proposed scheme.

  Y Harada , C Elly , G Ying , J. H Paik , R. A DePinho and Y. C. Liu

The transcription factor Foxp3 is essential for optimal regulatory T (T reg) cell development and function. Here, we show that CD4+ T cells from Cbl-b RING finger mutant knockin or Cbl-b–deficient mice show impaired TGF-β–induced Foxp3 expression. These T cells display augmented Foxo3a phosphorylation, but normal TGF-β signaling. Expression of Foxo3a rescues Foxp3 expression in Cbl-b–deficient T cells, and Foxo3a deficiency results in defective TGF-β–driven Foxp3 induction. A Foxo3a-binding motif is present in a proximal region of the Foxp3 promoter, and is required for Foxo3a association. Foxo1 exerts similar effects as Foxo3a on Foxp3 expression. This study reveals that Foxo factors promote transcription of the Foxp3 gene in induced T reg cells, and thus provides new mechanistic insight into Foxo-mediated T cell regulation.

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