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Articles by Y Yasuoka
Total Records ( 3 ) for Y Yasuoka
  S Chandar , L. S Yeo , C Leimena , J. C Tan , X. H Xiao , V Nikolova Krstevski , Y Yasuoka , M Gardiner Garden , J Wu , S Kesteven , L Karlsdotter , S Natarajan , A Carlton , S Rainer , M. P Feneley and D. Fatkin
 

Rationale: Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A and lamin C, are the most common cause of familial dilated cardiomyopathy (DCM). Mechanical stress-induced apoptosis has been proposed as the mechanism underpinning DCM in lamin A/C–deficient hearts, but supporting in vivo evidence has been lacking.

Objective: Our aim was to study interventions to modify mechanical stress in heterozygous Lmna knockout (Lmna+/–) mice.

Methods and Results: Cardiac structure and function were evaluated before and after exercise training, thoracic aortic constriction, and carvedilol treatment. Lmna+/– mice develop adult-onset DCM with relatively more severe disease in males. Lmna+/– cardiomyocytes show altered nuclear morphology and perinuclear desmin organization, with enhanced responses to hypo-osmotic stress indicative of cytoskeletal instability. Despite these structural defects that provide a template for mechanical stress-induced damage, young Lmna+/– mice subjected to 6 weeks of moderate or strenuous exercise training did not show induction of apoptosis or accelerated DCM. In contrast, regular moderate exercise attenuated DCM development in male Lmna+/– mice. Sustained pressure overload generated by thoracic aortic constriction depressed ventricular contraction in young wild-type and Lmna+/– mice with no sex or genotype differences in the time-course or severity of response. Treatment of male Lmna+/– mice from 12 to 40 weeks with the β-blocker, carvedilol, prevented the dilatation and contractile dysfunction that was observed in placebo-treated mice.

Conclusions: These data suggest that factors other than mechanical stress-induced apoptosis contribute to DCM and provide the first demonstration that regular moderate exercise and carvedilol can modify disease progression in lamin A/C–deficient hearts.

  Y Yasuoka , A Sorimachi , T Ishikawa , M Hosoda , S Tokonami , N Fukuhori and M. Janik
 

It was shown that radon and thoron concentrations exhaled from soil were separately measured using the AlphaGUARD and liquid scintillation counter (LSC) methods. The thoron concentrations from the RAD 7 were used to create the conversion equation to calculate thoron levels with the AlphaGUARD. However, the conversion factor was found to depend on the air flow rate. When air containing thoron of ~60 kBq m–3 was fed to the scintillation cocktail, thoron and thoron progeny could not be measured with the LSC method. The radon concentration of about 10 kBq m–3 was measured with three methods, first with the LSC method and then with two AlphaGUARDs (one in the diffusion mode and the other in the flow mode (0.5 l min–1)). There were no significant differences between these results. Finally, it was shown that the radon and thoron concentrations in air could be measured with the AlphaGUARD and LSC methods.

  M Hosoda , S Tokonami , A Sorimachi , T Ishikawa , S. K Sahoo , M Furukawa , Y Shiroma , Y Yasuoka , M Janik , N Kavasi , S Uchida and M. Shimo
 

Field measurements of thoron exhalation rates have been carried out using a ZnS(Ag) scintillation detector with an accumulation chamber. The influence of soil surface temperature and moisture saturation on the thoron exhalation rate was observed. When the variation of moisture saturation was small, the soil surface temperature appeared to induce a strong effect on the thoron exhalation rate. On the other hand, when the variation of moisture saturation was large, the influence of moisture saturation appeared to be larger than the soil surface temperature. The number of data ranged over 405, and the median was estimated to be 0.79 Bq m–2 s–1. Dependence of geology on the thoron exhalation rate from the soil surface was obviously found, and a nationwide distribution map of the thoron exhalation rate from the soil surface was drawn by using these data. It was generally high in the southwest region than in the northeast region.

 
 
 
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