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Articles by Y Kovas
Total Records ( 2 ) for Y Kovas
  H. A Ball , A Sumathipala , S. H Siribaddana , Y Kovas , N Glozier , P McGuffin and M. Hotopf
 

Background

Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts.

Aims

To examine heritability of depression in the first large, population-based twin study in a low-income country.

Method

Lifetime depression and a broader measure of depression susceptibility (D-probe) were assessed in 3908 adult twins in Sri Lanka (the CoTASS study).

Results

There were gender differences for the broad definition (D-probe), with a higher genetic contribution in females (61%) than males (4%). Results were similar for depression, but the prevalence was too low to estimate heritability for males.

Conclusions

Genetic influences on depression in women appear to be at least as strong in this Sri Lankan sample as in higher-income countries. Conclusions are less clear for men but suggest a larger role for environments rather than genes. The nature as well as the magnitude of environmental influences may also differ across populations.

  H. A Ball , A Sumathipala , S. H Siribaddana , Y Kovas , N Glozier , P McGuffin and M. Hotopf
 

Background

Fatigue is a common symptom in Western high-income countries but is often medically unexplained and little is known about its presentation in other populations.

Aims

To explore the epidemiology and aetiology of fatigue in Sri Lanka, and of its overlap with depression.

Method

A total of 4024 randomly selected twins from a population-based register in Sri Lanka (Colombo district) completed home interviews including the Chalder Fatigue Questionnaire.

Results

The prevalence of fatigue was similar to that in other countries, although prolonged fatigue may be less common. There was substantial comorbidity with a screen for lifetime depression. Non-shared environmental factors made the largest contributions, although genetic/family factors also contributed. The aetiology appeared consistent across the spectrum of severity.

Conclusions

The aetiology of fatigue is broadly similar in Sri Lanka and Western high-income countries. Abnormal experiences of fatigue appear to be the extreme form of more common fatigue, rather than representing independent entities with different genetic or environmental risk factors.

 
 
 
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