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Articles by Y Izumi
Total Records ( 3 ) for Y Izumi
  Y Yamauchi , M Kohno , T Hato , Y Hayashi , Y Izumi and H. Nomori

A 55-year-old woman with a 7 cm non-invasive thymoma and myasthenia gravis had been treated by extended thymectomy via median sternotomy 29 years ago. A microscopic 0.15 cm thymoma (microthymoma) was incidentally found in the thymus during surgery. Twenty-nine years later, a 5 cm thymoma developed in the anterior mediastinum and was surgically treated. The non-invasive first thymoma, the microthymoma and the non-invasive third thymoma were all classified as type AB thymomas according to the World Health Organization (WHO) classification and showed extremely similar histological findings. We think the mechanism underlying the local recurrence of non-invasive thymomas would be intrathymic metastasis because of their clinical and pathological features.

  Q. D Trinh , N. T. K Pham , B. Q Lam , T. P. K Le , K. H Truong , T. Q Le , H. T Vo , T. C Tang , T. M Ha , Y Izumi , M Mizuguchi , S Hayakawa and H. Ushijima

A molecular epidemiological study was conducted on 104 HIV-1 strains isolated from HIV-infected children hospitalized in Children Hospital 1 in Ho Chi Minh City, Vietnam during 2004–2005. Genetic subtyping based on env C2/V3 sequences revealed that CRF01-AE was the sole circulating recombinant form found in this study. Sequence analysis of the V3 loop showed that GPGQ tetramer was the most common V3 loop core motif identified in the HIV-1 strains studied (89.5%). The findings raise great concern about HIV-infected children in Vietnam and provide up-to-date molecular epidemiological information of HIV-1 circulating in Vietnam during the study period.

  K Migita , T Koga , T Torigoshi , Y Maeda , T Miyashita , Y Izumi , Y Aiba , A Komori , M Nakamura , S Motokawa and H. Ishibashi

Objective. Although serum amyloid A (SAA) has been used as a marker of inflammation, its role in leucocyte recruitment and angiogenesis has not been well established in RA. CCL20 is a chemokine involved in the migration of CCR6-expressing Th17 cells. To study the contribution of SAA to the recruitment of Th17 cells, we investigated the effects of SAA on CCL20 production by RA synoviotytes.

Methods. Synoviocytes isolated from RA patients were stimulated with recombinant SAA and cellular supernatants were analysed by CCL20-specific ELISA. CCL-20 mRNA expression was analysed by RT–PCR.

Results. SAA is a most potent inducer of CCL20 secretion in RA synoviocytes compared with other inflammatory cytokines (IL-1β, TNF- and IL-17A). SAA stimulation induced CCL20 mRNA expression in RA synoviocytes, which was not affected by polymyxin B pre-treatment. SAA-induced CCL20 production was down-regulated by NF-B inhibition and partially by c-jun N-terminal kinase (JNK) inhibition. SAA-induced CCL20 production was also suppressed by dexamethasone or FK506.

Conclusion. These findings suggest that SAA may be implicated in the recruitment of lymphocytes, including CCR6-expressing Th17 cells, in RA synovium by up-regulating CCL20 production in synoviocytes.

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