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Articles by Xu Xu
Total Records ( 2 ) for Xu Xu
  Min Zhu , Marc Bifano , Xu Xu , Yonghua Wang , Frank LaCreta , Dennis Grasela and Marc Pfister
  Entecavir is a guanosine nucleoside analogue approved for the treatment of chronic hepatitis B virus (HBV) infection. The impact of human immunodeficiency virus (HIV) coinfection on the pharmacokinetics (PK) of entecavir was examined by nonlinear mixed-effects modeling. Plasma concentration data from HIV- and HBV-coinfected patients were analyzed in conjunction with data from HBV-monoinfected patients, and HIV coinfection was tested as a covariate on oral clearance (CL/F). The estimated population averages of intercompartmental clearance and the volumes of distribution in the central and peripheral compartments obtained with a 1-mg dose were 34.2 liters/h (interindividual variability, 30.2%), 115 liters (interindividual variability, 39.2%), and 1,830 liters (interindividual variability, 74%), respectively. CL/F was found to be a function of creatinine clearance, but HIV confection did not show any effect on CL/F. The geometric mean (GM) of individual Bayesian estimates of the steady-state area under the concentration-time curve following 1-mg daily doses were 39.3 and 38.8 ng·h/ml in HIV- and HBV-coinfected and HBV-monoinfected patients, respectively. The adjusted GM ratio (1.01; 90% confidence interval, 0.91 to 1.12) was within the bioequivalence criteria boundary (0.80 to 1.25). In conclusion, the proposed model adequately described the entecavir PK in HBV- and HIV-coinfected patients and HBV-monoinfected patients, and the entecavir exposures were comparable in the two patient populations.
  Hongyu Chu , Zhijiang Xie , Xu Xu , Lidan Zhou and Qin Liu
  According to the application of the current high-power solid-state laser devices with precision optical elements, it proposes the concept of the Generalized Surface Defects. Based on the machine vision, a non-contact detection scheme is proposed for the surface detection on defect features concerning the past low speed, smaller size in detection and less inconvenience in the testing or operation. A gantry platform for large-size three-dimensional motion and a clamping frame are designed, obtaining images with the linear array CCD, constructing partially closed spaces by the Graham method, achieving defective images through the adaptive threshold segmentation, extracting the defect parameters from the geometric space and the gray space and classifying the defects by the hierarchical support vector machine. Experiments show that the instrument detects the largest size of 700x600 mm and is capable of completing the scanning of the whole size of such elements within 25 min. Average error of area is 12% and average recognition accuracy is 92.2%.
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