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Articles by Xin Wei
Total Records ( 3 ) for Xin Wei
  Tai-An Lintai , Galina Kourteva , Holly Hilton , Hongli Li , Nadine S. Tare , Valerie Carvajal , Julie S. Hang, Xin Wei , Xin Wei and Louis M. Renzetti
  CRTH2 is one of the prostaglandin D2 receptors and plays a proinflammatory role in allergic diseases. Gene expression markers in whole blood induced by CRTH2 activation have not previously been reported. Using microarray analyses of 54 675 genes, we revealed modest gene expression changes in human whole blood stimulated in vitro by a selective CRTH2 agonist, DK-PGD2. Five genes were found to exhibit 1.5- to 2.6-fold changes in expression. The expression of Charcot-Leyden crystal protein/galectin-10 (CLC/Gal-10) in particular was consistently enhanced in human whole blood stimulated by DK-PGD2, as confirmed by quantitative real-time polymerase chain reaction analyses. DK-PGD2-induced increases in blood CLC/Gal-10 mRNA levels were largely attenuated by the CRTH2 antagonist CAY10471.Thus, the DK-PGD2-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents.
  Xin Wei , Wei Jian-Zhong , Huang Xiao-Hui , Yin Zong-Jun , Sun Pei and Li Yu
  To investigate the characteristics of serology and molecular epidemiology of Haemophilus parasuis in Anhui area, this research adopts KRG serotyping and ERIC-PCR and PCR-RFLP genotyping to conduct systematic analyses on 18 HPS isolates from Anhui. The result shows that 55.6% bacterial strains can be serotyped where the most prevalent serotype is type 4 (27.78%) followed by type 14 (16.67%) and type 13 (11.11%). About 44.4% bacterial strains cannot be serotyped. With ERIC-PCR analyses, 18 HPS isolates contain 4-9 bands with the size ranging from 100-2000 bp and they belong to 11 different genotypes where IV is the dominant genotype (27.78%) followed by type 2 (16.67%) and type 1 (11.11%). With PCR-RFLP analyses, 18 HPS isolates lie in 6 different genotypes where the most prevalent genotype in Anhui area is DBP (44.4%) followed by BAE (22.22%) and BBB (16.67%). The result revels that HPS prevails in pigs in Anhui area and both its serotypes and genotypes are in polymorphism distribution. The result also shows that KRG serotypes, ERIC-PCR genotypes and PCR-RFLP genotypes of HPS are not significantly associated with each other but ERIC-PCR genotype is associated with the sources of bacterial strains with the same serotype. Compared with PCR-RFLP, ERIC-PCR better uncovers the genetic relationships of bacterial strains and hence reveals the genetic distance among different bacterial strains which can be especially applied to the inter-pig and inter-farm epidemic conditions of pathogenium.
  Jianxin Lin , Guangyi Lu , Lee M. Daniels , Xin Wei , John B. Sapp and Yuanjian Deng
  Preparations of trans-[PtX2(Imt)2] (Imt = 2-imidazolidinethione, X=Cl- or I-) and [Pt(Imt)4]I2 are described. These complexes were characterized by elemental analysis, thermal analysis, mid- and far-IR spectroscopy, and NMR (1H and 13C) spectroscopy. The crystal and molecular structure of [Pt(Imt)4]I2 · DMSO · H2O was determined by X-ray diffraction methods. The structural data reveal the following features: (a) the platinum atom in [Pt(Imt)4]2+ is essentially in a square-planar environment, (b) the entire dication possesses approximately C2h symmetry, (c) no appreciable hydrogen bonding exists between the iodide ions and the Imt ligands in the dication, (d) two pairs of two mutually cis Imt ligands are arranged above and below the PtS4 plane, respectively, and (e) two planes defined by two trans Imt rings are perpendicular to each other.
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