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Articles by Xin GUO
Total Records ( 5 ) for Xin GUO
  Xin Guo , Angus Duff and Mario Hair
  This study draws on the exchange relationships literature to create a model of what motivates corporate customers to continue their relationships with their primary banking services providers. The study reports the results of a questionnaire survey administered to financial managers (N = 259) in China. Results provide evidence for the existence of a number of antecedents and consequences of commitment in bank-corporate relationships. Notably, service quality is found to be a significant antecedent of affective commitment, which in turn leads to cooperation and continuance intentions. Implications for bank management are discussed along with avenues for future research.
  Xin Guo , Yang Xiang , Qian Chen and Wei Wei
  A Social network graph shows social interactions and relationships between individuals in a specific social environment, which is very helpful for analyzing social relationships, activities, structures, etc. The author quantized the strengths of social objects’ relationships in social environment using an improved vector space model. Gaussian mixture model was employed to set the threshold for identifying social relationships adaptively and divide social subgroups automatically. According to the threshold, social network graph would be constructed based on performance measures. It is concluded that hidden social relationships can be discovered effectively by using this approach which is very flexible and adaptive for dynamic information feedback mechanism.
  Donglin Wang , Jian Liang , Yusheng Jia and Xin Guo
  According to the Hefei subway deep foundation pit engineering, this study expounds the pile-anchor supporting scheme of prestressed anchor cable layout optimization. Combined with the actual situation of engineering, numerical simulation was carryed out by using FLAC3D software. The four different layout of prestressed anchor cable is used for simulation analysis, Detailed to carry out the horizontal displacement of the pile and anchor axial force analysis, discuss the anchor cable layout optimization. Calculation results provide a reference for support scheme of similar large deep foundation pit.
  Sarah S. Durkin , Xin Guo , Kimberly A. Fryrear , Valia T. Mihaylova , Saurabh K. Gupta , S. Mehdi Belgnaoui , Abdelali Haoudi , Gary M. Kupfer and O. John Semmes
  Human T-cell leukemia virus type-1 is the causative agent for adult T-cell leukemia. Previous research has established that the viral oncoprotein Tax mediates the transformation process by impairing cell cycle control and cellular response to DNA damage. We showed previously that Tax sequesters huChk2 within chromatin and impairs the response to ionizing radiation. Here we demonstrate that DNA-dependent protein kinase (DNA-PK) is a member of the Tax·Chk2 nuclear complex. The catalytic subunit, DNA-PKcs, and the regulatory subunit, Ku70, were present. Tax-containing nuclear extracts showed increased DNA-PK activity, and specific inhibition of DNA-PK prevented Tax-induced activation of Chk2 kinase activity. Expression of Tax induced foci formation and phosphorylation of H2AX. However, Tax-induced constitutive signaling of the DNA-PK pathway impaired cellular response to new damage, as reflected in suppression of ionizing radiation-induced DNA-PK phosphorylation and γH2AX stabilization. Tax co-localized with phospho-DNA-PK into nuclear speckles and a nuclear excluded Tax mutant sequestered endogenous phospho-DNA-PK into the cytoplasm, suggesting that Tax interaction with DNA-PK is an initiating event. We also describe a novel interaction between DNA-PK and Chk2 that requires Tax. We propose that Tax binds to and stabilizes a protein complex with DNA-PK and Chk2, resulting in a saturation of DNA-PK-mediated damage repair response.
  Jingwen ZENG , Danting HE , Xin GUO , Xinna GE and Hanchun YANG
  Regulatory T lymphocytes (T−regs) may be involved in suppressing the host’s immunity, which is important for viral clearance, and may therefore contribute to persistent viral infection. However, nothing is known regarding the situation of porcine T−regs during persistent infection with porcine reproductive and respiratory syndrome virus (PRRSV). This study, which used flow cytometry and real−time PCR, determined that the frequencies of CD4+CD25+ T−cells and porcine Forkhead/winged helix transcription factor (FoxP3) mRNA levels in peripheral blood significantly increased during PRRSV persistence, indicating that CD4+CD25+ T−regs might play an important role in PRRSV persistent infection. This study contributes to a better understanding of the immunological basis of PRRSV persistence.
 
 
 
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