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Articles by Xiaodong Wang
Total Records ( 2 ) for Xiaodong Wang
  Xiao Xia , Xiaodong Wang , Wei Wei and Xingming Zhou
  Online marketplaces of mobile applications have undergone dramatic growth in recent years, as exemplified by Apple AppStore and Google Android Market. However, systematical observation and analysis of such a market are still missing. Therefore, this study seeks better understanding of such marketplaces by measuring one of them, i.e., the Google Play Market, from various perspectives. Since this market has grown to a complex system with large amount of applications, this study measures it from the scope of complex networks. To this end, this study first constructs two app relationship networks and one user navigation network based on the data set crawled from the Google Android Market. This study then generates both micro-scope and macro-scope statistics and analysis on various essential metrics of those three networks. By this way, this study is in the purpose of revealing both the relationships among applications and the influences imposed on the user behaviors by the market. To the best of the knowledge, this study is the first to observe, analyze the mobile application market, especially from the view of complex network. Results of this study can serve as data supports for various future researches on mobile apps, which is a rising and problem abundant area in the era of mobile computing.
  Xiaodong Wang and Jeffrey J. Hayes
  Nucleosome arrays undergo salt-dependent self-association into large oligomers in a process thought to recapitulate essential aspects of higher-order tertiary chromatin structure formation. Lysine acetylation within the core histone tail domains inhibits self-association, an effect likely related to its role in facilitating transcription. As acetylation of specific tail domains may encode distinct functions, we investigated biochemical and self-association properties of model nucleosome arrays containing combinations of native and mutant core histones with lysine-to-glutamine substitutions to mimic acetylation. Acetylation mimics within the tail domains of H2B and H4 caused the largest inhibition of array self-association, while modification of the H3 tail uniquely affected the stability of DNA wrapping within individual nucleosomes. In addition, the effect of acetylation mimics on array self-association is inconsistent with a simple charge neutralization mechanism. For example, acetylation mimics within the H2A tail can have either a positive or negative effect on self-association, dependent upon the acetylation state of the other tails and nucleosomal repeat length. Finally, we demonstrate that glutamine substitutions and lysine acetylation within the H4 tail domain have identical effects on nucleosome array self-association. Our results indicate that acetylation of specific tail domains plays distinct roles in the regulation of chromatin structure.
 
 
 
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