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by
Xiao-Tong Yan |
Total Records (
2 ) for
Xiao-Tong Yan |
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Ge Yang
,
Zi Wang
,
Shen Ren
,
Xiao-tong Yan
,
Xing-yue Xu
,
Jun-nan Hu
,
Yan Zhang
and
Wei Li
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Background and Objective: Acetaminophen (APAP)-induced hepatotoxicity is a severe public health problem in western countries. Current treatment methods for poisoning are limited and novel therapeutic strategies are needed. The aim of the present study was to investigate the protective effect of ginsenosides from the fruits of Panax ginseng (GFG)against APAP-induced liver injury in mice and its potential molecular mechanisms of action. Materials and Methods: In this study, mice were orally administered with 150 or 300 mg kg–1 of GFG for 7 consecutive days, followed by a single injection of APAP (250 mg kg–1). Severe liver injury was observed after 24 h APAP injection and the protective effect of GFG was assessed. Results: The results showed that pre-treatment with GFG reduced the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Moreover, GFG showed anti-oxidant activities characterized by reducing hepatic MDA contents and increasing hepatic SOD and GSH levels, accompanied by inhibiting expression level of 4-HNE. Likewise, GFG decreased APAP-induced the expression of cytochrome P450 E1 (CYP2E1). Pre-treatment with GFG significantly inhibited pro-inflammatory factors tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), Bax, Bcl-2 and cyclooxygenase-2 (COX-2) levels expression of which contributed to ameliorating APAP caused hepatotoxicity. Furthermore, liver histopathological observation provided further evidence that GFG pretreatment significantly inhibited APAP-induced hepatocyte necrosis, inflammatory cell infiltration. Conclusion: The present study clearly showed that GFG exerted a protective effect against APAP-induced hepatotoxicity due to its anti-oxidant, anti-apoptotic and anti-inflammatory effects. |
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Shu-quan Xin
,
Zi Wang
,
Wei-Nan Hao
,
Xiao-Tong Yan
,
Qi Xu
,
Ying Liu
,
Wei Liu
,
Yan-Fei Li
,
Xin-Dian Li
and
Wei Li
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Background and Objective: The roots of Codonopsis lanceolata have been used in traditional medicine for treatment of many diseases in China. Till now, there is no evidence on the liver protection effect of C. lanceolata on alcohol-induced liver injury. The purpose of this study was to investigate the hepatoprotective effect of steamed C. lanceolata (SCL) on ethanol induced liver injury in mice. Materials and Methods: Experimental mice were pretreated with different doses of SCL (100-400 mg kg–1) for 2 weeks by gavage feeding. Biochemical markers and enzymatic antioxidants from serum, liver tissue were determined. Results: The results showed that the activities of ALT, AST and TG in serum, MDA level in liver tissue, decreased significantly (p<0.05) in the SCL-treated group compared with the alcohol group. On the contrary, the GSH level was increased markedly (p<0.05). Histopathological examination revealed that SCL (400 mg kg–1) pre-treatment noticeably prevented alcohol-induced hepatocyte apoptosis and fatty degeneration. Moreover, LC-MS/MS analysis of SCL showed that it mainly contain Lobetyolin, Tangshenoside, Lancemasides F, Lancemasides B (Lancemasides E, Codonolaside), Lancemasides G, Lancemasides A (Codonoposide, Codonolaside) and Codonoposide. Conclusion: These results provide the evidence on possible application of SCL on acute alcohol-induced oxidative stress and liver damage in clinic. |
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