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Articles by Xianquan Wang
Total Records ( 1 ) for Xianquan Wang
  Lin Yuan , Wei Li , Xianquan Wang , Zhentao Man , Yixin Li and Shui Sun
  Background and Objective: Osteoarthritis is a chronic joint disorder and the conventional drug used for the management of it has several limitations. This study used a rat model of osteoarthritis (OA) to investigate the protective effect of Pueraria lobata Ohwi (PF), a plant commonly referred to as kudzu in the treatment of this disease. Materials and Methods: The OA was induced by injecting 50 μL of monosodium iodoacetate into the intra-articular space through the patellar ligament. The rats were then treated with 250 and 500 PF mg kg–1 for the next 21 days. The weight-bearing distribution ratio and serum cytokine concentrations were assessed at 7, 14 and 21 days. The expression of inflammatory mediators including inducible nitric oxide synthase, cyclooxygenase-2 and matrix metalloproteinases-3 and 9, in the knee tissues of the OA rats was also evaluated, together with the histopathological changes as seen on haematoxylin and eosin-stained sections. Results: The results showed that the weight-bearing distribution ratio was significantly higher in the PF groups than in the OA group. The expression of inflammatory mediators was significantly lower in the knee tissues of the PF group than in those of the OA group, a result that was confirmed histopathologically. Conclusion: Based on these findings, PF by inhibiting the expression of pro-inflammatory mediators and cytokines, merits further examination for its efficacy in the treatment of OA in humans.
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