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Articles by Xi Peng
Total Records ( 2 ) for Xi Peng
  Zhicai Zuo , Hengmin Cui , Xi Peng , Junliang Deng , Jing Fang , Ya Wang and Zhihua Ren
  The objective of this study was to determine cytokine and chemokine microarray profiles in lung and Hilar Nodes (HN) from pigs infected with Actinobacillus Pleuropneumoniae (APP). Twenty pigs were randomly assigned to one of two groups: Control Group (CG) and inoculated with APP (TG). The infected-APP pigs’ lung exhibited significantly (p<0.05) greater levels of chemokines CCL2, CCL20, IL8 and slightly increase levels of chemokines CCL4, CCL5 and CXCL2 while significantly(p<0.05) decrease levels of chemokines CXCL10 and CXCL12. APP infection significantly (p<0.05 or 0.01) stimulated expression of cytokines IL-18, IL-6, TNF, GM-CSF, CASP3, CASP8 and significantly (p< 0.05 or 0.01) suppressed expression of cytokines CD40, IRF1 in lung. Cytokines in infected-APP pigs’ lung, IL-1A, IL-27, IRF3, IL-10 were slightly increased and CASP1, IRF7, IL-12B, IL-2 were slightly decreased. Relative cytokine and chemokine microarray data in HN indicated that APP infection significantly (p<0.05) stimulated expression of cytokine IL-6 and significantly (p<0.05 or 0.01) suppressed expression of cytokines CXCL12, CD40 and CASP1. In conclusion, 26 cytokine and chemokines mRNA expression levels in lung and HN obtained from infected-APP or control swines were elucidated in this study. This research provided evidence that the increased severity of lesions in the infected-APP swines was associated mainly with alterations of cytokine and chemokines microarray profiles, especialy in lung. The changes of all the cytokines in lung and HN can lead stem cells to produce granulocytes (neutrophils, eosinophils and basophils) and monocytes and also promoted neutrophil and macrophages to phagocytose bacterial and foreign antigen at the site of inflammation. Defense function of pig infection with APP was enhanced while immune function was weakened.
  Xun Wang , Hengmin Cui , Haifeng Liu , Ling Zhao , Xi Peng , Hengyong Xu , Yan Wang , Yuhao Wang , Ling Niang and Qian Rong
  To study the effect of the crude polysaccharides from Poria cocos (PCCP) on mRNA expression of adipogenic factors during 3T3-L1 preadipocyte differentiation. 3T3-L1 preadipocytes were induced to differentiate with MDI (3-isobutyl-1-Methylxanthine, Dexamethasone and Insulin) induction media contained PCCP (50 μg mL-1) and cultured for 8 days. The extent of the differentiation was assessed by Nile Red staining and GPDH activity. In addition, researchers used real-time quantitative PCR to analyzed the expression of genes related to adipocyte differentiation. The results showed that treatment of differentiating 3T3-L1 preadipocytes with PCCP (50 μg mL-1) resulted in an increase in the expression of the adipocyte genes such as Fatty Acid System Synthase (FAS), adipocyte fatty acid binding Protein (aP2), insulin-responsive Glucose Transporter (GLUT4) and transcriptional factor genes such as CCAAT/Enhancer Binding Protein α (C/EBPα), peoxisome Proliferator-Activated Receptor gamma (PPARγ) and Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) to some degree. Overall, the data suggested that there was the tendency of increasing the expression of genes related to adipocyte differentiation in PCCP treated cells.
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