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Articles by X. Qu
Total Records ( 1 ) for X. Qu
  Y Fang , B Kong , Q Yang , D Ma and X. Qu
  BACKGROUND

In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion.

METHODS

Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion.

RESULTS

The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207–3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092–7.011).

CONCLUSIONS

The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.

 
 
 
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