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Articles by X. Y Huang
Total Records ( 2 ) for X. Y Huang
  T Maretzky , S. M Le Gall , S Worpenberg Pietruk , J Eder , C. M Overall , X. Y Huang , Z Poghosyan , D. R Edwards and C. P. Blobel

ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice variant affects the function of ADAM15. Here, we show that ADAM15B has enhanced catalytic activity in cell-based assays compared with ADAM15A, which lacks a Src-binding site, using shedding of fibroblast growth factor receptor 2iiib variant as an assay for catalytic activity. Moreover, the enhanced activity of ADAM15B compared with ADAM15A depends on Src because it is abolished by Src-kinase inhibitors and in Src–/– cells, but not in Src–/– cells rescued with Src. These findings provide insights into the mechanism of how a splice variant linked to clinical agressiveness in breast cancer causes increased activity of ADAM15B, and suggest that inhibitors of the ADAM15 protease activity or of the interaction of ADAM15B with Src could be useful to treat breast cancer in patients with dysregulated ADAM15B. [Cancer Res 2009;69(11):4573–6]

  X. Y Huang , D. Y Chao , J. P Gao , M. Z Zhu , M Shi and H. X. Lin

Abiotic stresses, such as drought and salinity, lead to crop growth damage and a decrease in crop yields. Stomata control CO2 uptake and optimize water use efficiency, thereby playing crucial roles in abiotic stress tolerance. Hydrogen peroxide (H2O2) is an important signal molecule that induces stomatal closure. However, the molecular pathway that regulates the H2O2 level in guard cells remains largely unknown. Here, we clone and characterize DST (drought and salt tolerance)—a previously unknown zinc finger transcription factor that negatively regulates stomatal closure by direct modulation of genes related to H2O2 homeostasis—and identify a novel pathway for the signal transduction of DST-mediated H2O2-induced stomatal closure. Loss of DST function increases stomatal closure and reduces stomatal density, consequently resulting in enhanced drought and salt tolerance in rice. These findings provide an interesting insight into the mechanism of stomata-regulated abiotic stress tolerance, and an important genetic engineering approach for improving abiotic stress tolerance in crops.

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