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Articles by X Qiu
Total Records ( 2 ) for X Qiu
  Y Wang , J Li , Y Cui , T Li , K. M Ng , H Geng , H Li , X. s Shu , W Liu , B Luo , Q Zhang , T. S. K Mok , W Zheng , X Qiu , G Srivastava , J Yu , J. J.Y Sung , A. T.C Chan , D Ma , Q Tao and W. Han

Closely located at the tumor suppressor locus 16q22.1, CKLF-like MARVEL transmembrane domain-containing member 3 and 4 (CMTM3 and CMTM4) encode two CMTM family proteins, which link chemokines and the transmembrane-4 superfamily. In contrast to the broad expression of both CMTM3 and CMTM4 in normal human adult tissues, only CMTM3 is silenced or down-regulated in common carcinoma (gastric, breast, nasopharyngeal, esophageal, and colon) cell lines and primary tumors. CMTM3 methylation was not detected in normal epithelial cell lines and tissues, with weak methylation present in only 5 of 35 (14%) gastric cancer adjacent normal tissues. Furthermore, immunohistochemistry showed that CMTM3 protein was absent in 12 of 35 (34%) gastric and 1 of 2 colorectal tumors, which was well correlated with its methylation status. The silencing of CMTM3 is due to aberrant promoter CpG methylation that could be reversed by pharmacologic demethylation. Ectopic expression of CMTM3 strongly suppressed the colony formation of carcinoma cell lines. In addition, CMTM3 inhibited tumor cell growth and induced apoptosis with caspase-3 activation. Thus, CMTM3 exerts tumor-suppressive functions in tumor cells, with frequent epigenetic inactivation by promoter CpG methylation in common carcinomas. [Cancer Res 2009;69(12):5194–201]

  M Chen , X Qiu , W Xu , L Wang , J Zhao and X. Li

Test case generation based on design specifications is an important part of testing processes. In this paper, Unified Modeling Language activity diagrams are used as design specifications. By setting up several test adequacy criteria with respect to activity diagrams, an automatic approach is presented to generate test cases for Java programs. Instead of directly deriving test cases from activity diagrams, this approach selects test cases from a set of randomly generated ones according to a given test adequacy criterion. In the approach, we first instrument a Java program under testing according to its activity diagram model, and randomly generate abundant test cases for the program. Then, by running the instrumented program we obtain the corresponding program execution traces. Finally, by matching these traces with the behavior of the activity diagram, a reduced set of test cases are selected according to the given test adequacy criterion. This approach can also be used to check the consistency between the program execution traces and the behavior of activity diagrams.

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