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Articles by Wenhua Yu
Total Records ( 2 ) for Wenhua Yu
  Shijun Li , Wenhua Yu , Cui Wang , Zhenhua Liang , Xiuli Peng , Yanping Feng and Yanzhang Gong
  Stem Cell Factor (SCF) also called Steel Factor (SF), Mast cell Growth Factor (MGF) and KIT tyrosine Kinase receptor Ligand (KL) is a hematopoietic growth factor and ligand for the KIT tyrosine kinase receptor. In this study, the partial complementary DNA (cDNA) of SCF was cloned from the eye of duck by homology cloning and Rapid Amplification of Cdna Ends (RACE) approaches. Comparing with zebra finch, quail, chicken and mammalian SCF cDNA sequence, the phylogenetic tree displayed that duck SCF is highly conserved, it shares 63.8-94.3% similarity with the above species cDNA sequence. The rooted phylogenetic neighbor-Joining tree with bootstrap was done using SCF CDS sequences from duck and other species by DNAMAN software. The results showed that duck has close relationship with chicken, quail and zebro finch. The semi-quantitative RT-PCR analysis indicated that SCF was a universally expressed gene, it was detected in heart, liver, spleen, kidney, brain, back skin, muscle, eye, glandular stomach, belly skin. Q-PCR was employed to analyze the SCF gene expression in six type duck hair bulbs. The results showed that its expression had significant difference between W-W which is white hair bulb taken from white plumage with yellow beak and other types (BL-Bl which is black feather hair bulb taken from black plumage with black beak, W-L which is white feather hair bulb taken from white plumage with black beak ducks, W-WB which is white feather taken from white-black plumage with black beak, B-WB which is black feather taken from white-black plumage with black beak), p<0.001). The expression of SCF in BR (brown feather hair bulb taken from brown plumages with black beak ducks) has significant difference comparing with the above 5 hair bulb types (p<0.05). There is no significant difference between any of the following types which including BL-BL, W-L, W-WB and B-WB. The results indicated that SCF may be a critical gene on regulation gene expression for duck plumage diversity.
  Yupeng Chen , Lei Shi , Lirong Zhang , Ruifang Li , Jing Liang , Wenhua Yu , Luyang Sun , Xiaohan Yang , Yan Wang , Yu Zhang and Yongfeng Shang
  SOX genes encode a family of high-mobility group transcription factors that play critical roles in organogenesis. The functional specificity of different SOX proteins and the tissue specificity of a particular SOX factor are largely determined by the differential partnership of SOX transcription factors with other transcription regulators, many of which have not yet been discovered. Virtually all members of the SOX family have been found to be deregulated in a wide variety of tumors. However, little is known about the cellular and molecular behaviors involved in the oncogenic potential of SOX proteins. Using cell culture experiments, tissue analysis, molecular profiling, and animal studies, we report here that SOX2 promotes cell proliferation and tumorigenesis by facilitating the G1/S transition and through its transcription regulation of the CCND1 gene in breast cancer cells. In addition, we identified β-catenin as the transcription partner for SOX2 and demonstrated that SOX2 andβ-catenin act in synergy in the transcription regulation of CCND1 in breast cancer cells. Our experiments not only determined a role for SOX2 in mammary tumorigenesis but also revealed another activity of the multifunctional protein, β-catenin.
 
 
 
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