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Articles by Weihua Li
Total Records ( 3 ) for Weihua Li
  Zhenhua Gong , Lijuan Zhang , Ping Lu , Yonghao Hu , Liping Wang and Weihua Li
  Marek’s Disease (MD) is one of the main infectious diseases that threaten the healthy development of the Chinese poultry industry. The evolution of epidemic strains of the MD Virus (MDV) in China is different from the evolution of strains overseas. The meq gene sequence of pathogenic strains is different from that of the attenuated vaccine strain (MDV-1). The meq and L-meq gene sequences of the MDV in the lymphoid tissue of chickens in latency period are homologous. The meq gene was only found in the lymphoid tissue of chickens during the onset period.
  Weihua Li , Yang Li , Bohua Zhang , Xuan Dong , Zhizhong Cui and Peng Zhao
  To investigate the Reticuloendotheliosis virus infection status in large-scale breeder chicken farms of China, 563 serum samples from 4 great-grandparents breeder farms, 6557 serum samples from 8 grandparents breeder farms, 312 serum samples from parents breeder farms, totally 7432 serum samples were collected and examined using the Reticuloendotheliosis Virus Antibody Test kit. The results showed that REV-antibody positive rates of great-grandparents breeder flocks, grandparent breeder flocks and parents breeder flocks were 0-31, 0-47 and 4.23-42.50%, respectively. REV-antibody positive rate has close relationship with incidence of REV infection history and tumor complaints. This study suggests that REV infection is very common in China large-scale breeder chicken farms and the prevention of REV should be given more attention this is the largest scale serological survey for breeder chickens in China so far.
  Xin Fu , Weihua Li , Jian Zhang and YingHui Xu
  To study the role of P21/53 in directly regulating and controlling TIMP-2 and the important mechanism for promoting invasion of GSCs by P21/53. Transwell in vitro invasion experiment was used to test invasion ability of GSCs and GCs as well as effect of P21/53 on GSCs invasion. Techniques of qRT-PCR and Western blot were used to test and transfect expression variation of TIMP-2, MMP2 and MMP9 in GSCs of P21/53 inhibitor. The luciferase reporter gene experiment was used to test the role of P21/53 in directly regulating and controlling TIMP-2. The number of invasive GSCs significantly decreased following transfection of P21/53 inhibitor (p<0.05). The expression levels of TIMP-2 mRNA in the U87 cell line and GSCs from the two primary glioma specimens rose compared with the control group, respectively while the expression levels of MMP2 mRNA and MMP9 mRNA fell compared with the control group (p<0.05) following transfection of P21 inhibitor. Expression of protein level of TIMP-2, MMP2 and MMP9 were consistent with mRNA level and had significant difference compared with those of the control group following transfection of P21 inhibitor and P53 inhibitor. The luciferase activity of the reporter vector containing wiled-type TIMP-2-3'UTR increased significantly following transfection of P21/53 while the luciferase activity of the reporter decreased significantly following transfection of P21/53 simulator (p<0.05). High expression of P21/53 promotes invasiveness of GSCs and its mechanism is achieved by down-regulating expressions of TIMP-2 and up-regulating expressions of MMP2 and MMP9 as a minimum.
 
 
 
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