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Articles by Wei Zheng
Total Records ( 3 ) for Wei Zheng
  Baiyin Yang , Wei Zheng and Chris Viere
 

The problem and the solution. Based on a newly developed holistic theory of knowledge and learning, this article critically evaluates selected models of knowledge management (KM) and proposes a holistic KM model. Most existing KM models tend to narrowly define knowledge from conceptual and perceptual perspectives and fail to recognize affectual knowledge such as values and visions. Furthermore, most models view KM as a linear or cyclical process and thus fail to identify the multidimensional nature of the knowledge dynamics between individuals and organizations. Implications of the holistic model for human resource development are discussed.

  Shimin Yang , Xiangming Wen , Wei Zheng and Zhaoming Lu
  Challenges associated with the deployment of Machine Type Communication (MTC) over 3GPP cellular network focus on the overload control and congestion mitigation introduced by potential numbers of ‘smart devices’. Bulk processing mechanism, common to handling a group of similar control sessions, is a promising solution, however, there are still little work exploring the protocol-layer procedure optimization for the signaling sessions of group-based MTC application. This study mainly examines the in-building smart monitoring scenario and puts forward some novel schemes that efficiently aggregate and parse a bulk of Session Initial Protocol (SIP) sessions simultaneously from numerous MTC machines. By investigating the unique features of the group-based MTC applications and the media description fields of the Session Discovery Protocol (SDP), this study generates some new extension attributes which are used as the group identifier for a bulk of MTC devices with common behaviors and then illustrates the aggregate procedure for SIP bulk sessions to control overload and then, in addition, carefully presents a Group-based On-demand Parsing Mechanism (GOPM) to efficiently process concurrent SIP sessions in downlink direction. Theory analysis and performance evaluation both prove that the MTC signaling traffics can be controlled when the network is overloaded and therefore the network congestion can be reduced effectively.
  Eseng Lai , M. Gerard Waters , James R. Tata , Waldemar Radziszewski , Inna Perevozskaya , Wei Zheng , Larissa Wenning , Daniel T. Connolly , Graeme Semple , Amy O. Johnson-Levonas , John A. Wagner , Yale Mitchel and John F. Paolini
 

Background

Development of niacin-like agents that favorably affect lipids with an improved flushing profile would be beneficial.

Objective

To evaluate a niacin receptor partial agonist, MK-0354, in Phase I and II studies.

Methods

The pharmacokinetic/pharmacodynamic effects of single and multiple doses (7 days) of MK-0354 (300-4000 mg) were evaluated in two Phase I studies conducted in healthy men. A Phase II study assessed the effects of MK-0354 2.5 g once daily on lipids during 4 weeks in 66 dyslipidemic patients.

Results

MK-0354 single doses up to 4000 mg and multiple doses (7 days) up to 3600 mg produced robust dose-related reductions in free fatty acid (FFA) over 5 hours. Single doses of MK-0354 300 mg and extended release-niacin (Niaspan) 1 g produced comparable reductions in FFA. Suppression of FFA following 7 daily doses of MK-0354 was similar to that after a single dose. In the Phase II study, MK-0354 2.5 g produced little flushing but no clinically meaningful effects on lipids (placebo-adjusted percent change: high-density lipoprotein cholesterol, 0.4%, 95% confidence interval −5.2 to 6.0; low-density lipoprotein cholesterol, −9.8%, 95% confidence interval −16.8 to −2.7; triglyceride, −5.8%, 95% confidence interval −22.6 to 11.9).

Conclusion

Treatment with MK-0354 for 7 days resulted in plasma FFA suppression with minimal cutaneous flushing. However, 4 weeks of treatment with MK-0354 failed to produce changes in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or triglycerides.

 
 
 
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