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Articles by Wei Qi
Total Records ( 3 ) for Wei Qi
  Qin-Hua Huang , Wei Qi , Guo-Wei Mo , Guan-Feng Li , Li-Song Huang and Xin-Li Liang
  The 40 healthy female New Zealand white rabbits aged 30 days were randomly divided into normal control group, fed group and restricted feeding group with 10 rats in each group. Respectively by different feeding methods: the control group was fed with the nutritional standard of rabbits and fed group was increased by 40% on the basis of normal control group, while the control group was reduced by 40%. The body weight and serum leptin level and reproductive performance were measured in each group at the initial stage, the gestation period and the late delivery. The results showed that: in the 3 groups of body weight difference, the greater the weight, the early stage, the early stage of the early emergence of the fed group whose serum leptin level was 28.23, 8.76 ng mL–1 69%, the difference was very significant (p<0.01), compared with 37% 17.65 ng mL–1, the difference was also reached a significant level (p<0.05). Feeding group appeared early, sex hormones FSH (Follicle Stimulating Hormone) and LH (Luteinizing Hormone) level is much higher than did not occur in the early stage control group and restricted feeding group and the difference was significant (p<0.01) and limited feeding group and control group was no significant difference between. From the beginning to the late delivery, LH and FSH were first raised and then leveled off and the Leptin was first raised and then decreased and finally remained relatively stable, apparently with the same changes in FSH and LH. There was no significant difference in the level of FSH and LH between the pregnant women and the late delivery. Pregnancy pregnancy rate: the highest pregnancy rate of feeding group (100%), followed by the control group (90%) and restriction group (50%). Late childbirth of fetal weight: over feeding group and feed restriction group of pups born weight were significantly higher and lower than that in the control group (p<0.05) but nest litter size in between the 3 groups had no significant difference. The and LH levels of the serum lepin levels are associated with increased levels of FSH and Leptin in animals. When the animal is in energy and and has the same change rule. When the animals are in energy and the LH and FSH have the same change rule. When the animals are energetic and and have the same change rule. When the animals are in energy. High levels of the situation, resulting in a decline in the reproductive performance of animals.
  Nan Zhou , Jin-Chun Zhang , Yong-Xi Liu , Yang Yu , Yuan Deng , Ling Feng , Wei Qi , Chuan-Fang Wu and Jin-Ku Bao
  Developing multi-target drugs to obtain potentially innovative medicines has become a trend in the treatment of multifactorial diseases. The open-access resources are used by computational biologists to uncover relationships among various datasets for further drug discovery. In this study, researchers systematically analyzed approved retail drugs of China Food and Drug Administration (CFDA) in terms of biological interactions networks and found that CFDA-approved drugs had significant multi-target properties. To determine the features of these drugs and understand their indication on multi-target drug design, researchers computationally built a bipartite graph composed of drugs and target proteins linked by drug-target binary associations. Furthermore, researchers chose 19 drugs whose target numbers were ≥15 and then integrated human Protein-Protein Interactions (PPIs) datasets from DIP, IntAct, BioGRID, MINT and HPRD to generate a human PPIs network to analyze targets of these drugs. Graph theory analysis identified significant nodes including five multi-target drugs and eight drug targets which indicated that some of the CFDA-approved drugs were potentially valuable for the future development of multi-target drugs.
  Qin-Hua Huang , Wei Qi , Guo-Wei Mo , Guan-Feng Li , Li-Song Huang and Xin-Li Liang
  The 40 healthy female New Zealand white rabbits aged 30 days were randomly divided into normal control group, fed group and restricted feeding group with 10 rats in each group. Respectively by different feeding methods: the control group was fed with the nutritional standard of rabbits and fed group was increased by 40% on the basis of normal control group while the control group was reduced by 40%. The body weight and serum Leptin level and reproductive performance were measured in each group at the initial stage, the gestation period and the late delivery. The results showed that: in the 3 groups of body weight difference, the greater the weight, the early stage, the early stage of the early emergence of the fed group whose serum Leptin level was 28.23 ng/mL, 8.76 ng/mL (69%), the difference was very significant (p<0.01), compared with 37% 17.65 ng/mL, the difference was also reached a significant level (p<0.05). Feeding group appeared early, sex hormones FSH (Follicle Stimulating Hormone) and LH (Lteinizing Hormone) level is much higher than did not occur in the early stage control group and restricted feeding group and the difference was significant (p<0.01) and limited feeding group and control group was no significant difference between. From the beginning to the late delivery, LH and FSH were first raised and then leveled off and the Leptin was first raised and then decreased and finally, remained relatively stable, apparently with the same changes in FSH and LH. There was no significant difference in the level of FSH and LH between the pregnant women and the late delivery. Pregnancy pregnancy rate; The highest pregnancy rate of feeding group (100%), followed by the control group (90%) and restriction group (50%). Late childbirth of fetal weight: over feeding group and feed restriction group of pups born weight were significantly higher and lower than that in the control group (p<0.05) but nest litter size in between the 3 groups had no significant difference. The and LH levels of the serum lepin levels are associated with increased levels of FSH and Leptin in animals. When the animal is in energy and and has the same change rule. When the animals are in energy and the LH and FSH have the same change rule. When the animals are energetic and and have the same change rule. When the animals are in energy. High levels of the situation, resulting in a decline in the reproductive performance of animals.
 
 
 
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