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Articles by Wei Peng
Total Records ( 2 ) for Wei Peng
  Wei Peng , Xuegang Wang , Kesong Chen and Bin Tang
  A wideband imaging architecture based on subbanding and Doppler filter bank using FFT is developed and its performance is analyzed in detail. The theoretical analysis shows that owing to Doppler dispersion, the target’s range profile will produce distortion with the increase in target velocity. The distortion includes range shift and amplitude deformation. At the same time, two related theoretical formulas are deduced for the calculation of the range shift value and evaluation of the amplitude deformation extent of a moving target's range profile formed by the proposed imaging architecture and thereby the maximum critical velocity is derived. When target velocity is less than the maximum critical velocity, a moving target’s range profile with acceptable distortion can be obtained. Specific conclusions are verified with some simulations.
  Yong Yang , Fang Wu , Tarsha Ward , Feng Yan , Quan Wu , Zhaoyang Wang , Tanisha McGlothen , Wei Peng , Tianpa You , Mingkuan Sun , Taixing Cui , Renming Hu , Zhen Dou , Jingde Zhu , Wei Xie , Zihe Rao , Xia Ding and Xuebiao Yao
  Chromosome movements in mitosis are orchestrated by dynamic interactions between spindle microtubules and the kinetochore, a multiprotein complex assembled onto centromeric DNA of the chromosome. Here we show that phosphorylation of human HsMis13 by Aurora B kinase is required for functional kinetochore assembly in HeLa cells. Aurora B interacts with HsMis13 in vitro and in vivo. HsMis13 is a cognate substrate of Aurora B, and the phosphorylation sites were mapped to Ser-100 and Ser-109. Suppression of Aurora B kinase by either small interfering RNA or chemical inhibitors abrogates the localization of HsMis13 but not HsMis12 to the kinetochore. In addition, non-phosphorylatable but not wild type and phospho-mimicking HsMis13 failed to localize to the kinetochore, demonstrating the requirement of phosphorylation by Aurora B for the assembly of HsMis13 to kinetochore. In fact, localization of HsMis13 to the kinetochore is spatiotemporally regulated by Aurora B kinase, which is essential for recruiting outer kinetochore components such as Ndc80 components and CENP-E for functional kinetochore assembly. Importantly, phospho-mimicking mutant HsMis13 restores the assembly of CENP-E to the kinetochore, and tension developed across the sister kinetochores in Aurora B-inhibited cells. Thus, we reason that HsMis13 phosphorylation by Aurora B is required for organizing a stable bi-oriented microtubule kinetochore attachment that is essential for faithful chromosome segregation in mitosis.
 
 
 
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