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Articles by Wei Gu
Total Records ( 3 ) for Wei Gu
  Jie Yu , Wei Gu and Shu-ming Fei
  In view of frequent wind-curtailed phenomenon in the power generation process, this study constructs a power generation scheduling model which considers the curtailment cost of wind power. In the objective function, When the wind power is curtailed, the total power generation costs will be increased as the punishment mechanism of wind power curtailment. At the same time, the utilization ratio limit of wind power will also be taken into consideration for the constraint conditions. Through the Lagrange function, we can deduce the calculation formula of the curtailment cost of wind power. The numerical example shows that, compared with the traditional scheduling strategy, this new strategy which considers the curtailment cost of wind power, would effectively increase the utilization rate of wind power and reduce the output of the thermal power generation.
  Wei Gu , Amber L. Wells , Feng Pan and Robert H. Singer
  ZBP1 (zipcode binding protein 1) is an RNA-binding protein involved in many posttranscriptional processes, such as RNA localization, RNA stability, and translational control. ZBP1 is abundantly expressed in embryonic development, but its expression is silenced in most adult tissues. Reactivation of the ZBP1 gene has been reported in various human tumors. In this study, we identified a detailed molecular mechanism of ZBP1 transactivation in breast cancer cells. We show that β-catenin, a protein that functions in both cell adhesion and transcription, specifically binds to the ZBP1 promoter via a conserved β-catenin/TCF4 response element and activates its gene expression. ZBP1 activation is also closely correlated with nuclear translocation of β-catenin in human breast tumors. We further demonstrate feedback regulation by finding that ZBP1 physically associates with β-catenin mRNA in vivo and increases its stability. These experiments suggest that in breast cancer cells, the expression of ZBP1 and the expression of β-catenin are coordinately regulated. β-Catenin mediates the transcription of the ZBP1 gene, while ZBP1 promotes the stability of β-catenin mRNA.
  Kai Li , Alex Casta , Rui Wang , Enerlyn Lozada , Wei Fan , Susan Kane , Qingyuan Ge , Wei Gu , David Orren and Jianyuan Luo
  Werner syndrome is an autosomal recessive disorder associated with premature aging and cancer predisposition caused by mutations of the WRN gene. WRN is a member of the RecQ DNA helicase family with functions in maintaining genome stability. Sir2, an NAD-dependent histone deacetylase, has been proven to extend life span in yeast and Caenorhabditis elegans. Mammalian Sir2 (SIRT1) has also been found to regulate premature cellular senescence induced by the tumor suppressors PML and p53. SIRT1 plays an important role in cell survival promoted by calorie restriction. Here we show that SIRT1 interacts with WRN both in vitro and in vivo; this interaction is enhanced after DNA damage. WRN can be acetylated by acetyltransferase CBP/p300, and SIRT1 can deacetylate WRN both in vitro and in vivo. WRN acetylation decreases its helicase and exonuclease activities, and SIRT1 can reverse this effect. WRN acetylation alters its nuclear distribution. Down-regulation of SIRT1 reduces WRN translocation from nucleoplasm to nucleoli after DNA damage. These results suggest that SIRT1 regulates WRN-mediated cellular responses to DNA damage through deacetylation of WRN.
 
 
 
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