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Articles by Wei Feng
Total Records ( 4 ) for Wei Feng
  Wei Feng , Yun Li , Xuefeng Li and Longyun Li
  Background and Objective: Minimal invasive parathyroidectomy under local anesthesia with sedation has the same cure rates as the general anesthesia but has better postoperative complications control. The objective of the study was to justify the hypothesis that levobupivacaine infiltration and midazolam sedation technique is effective in minimally invasive parathyroidectomy. Materials and Methods: Total, 248 patients who had clinically confirmed primary hyperparathyroidism were included in a trial. Patients had received intravenous propofol (PI group, n = 124) or infiltrated preoperatively by levobupivacaine with midazolam sedation (LM group, n = 124) followed image-guided minimal invasive parathyroidectomy by an ENT surgeon. Postoperative pain, anesthesia-emergent adverse effects, surgical cure and length of hospital stay were recorded. Results: Cure rate was equal in both groups (96 vs. 95%). Hospitalization was fewer in patients of LM group (1.81±0.11 days) than those of PI group (2.36±0.21 days, p<0.0001, q = 40.59). Overall satisfaction of patients was strongly in favor of levobupivacaine infiltration with midazolam sedation than propofol-based general anesthesia (VAS score 3.11±0.41 vs. 5.46±1.12, p<0.0001, q = 37.87). Patients of PI group had required higher intravenous pain medication (32.12±4.15 mg vs. 19.11±2.12 mg morphine/morphine equivalent, p<0.0001, q = 36.712) and more numbers of anti-emetic doses than LM group. Conclusion: Preoperative levobupivacaine infiltration with midazolam sedation technique was effective and had high advantages in minimally invasive parathyroidectomy.
  Daxing Zhao , Wei Feng , Guodong Sun and Yu Peng
  Micro-electronic connector is widely used in electronic products and electrical equipments. The traditional quality detection method for micro-electronic connector relies on manual inspection, which is inefficient and susceptible to subjective factors. A high precision measurement system of micro-electronic connector has been developed based on machine vision in order to improve detection efficiency and measurement accuracy. Firstly the system architecture for high precision measurement is presented. Then the segmented image acquisition by cameras is introduced and unique ROI setting function of this system can realize the detection and measurement for various types of micro-electronic connectors. Finally an algorithm based on image processing is designed to achieve seamless splicing of segmental images. The experiments have proved the defect recognition rate of proposed system can surpass 95% and the measurement accuracy reaches 0.007 mm. The system performance can meet the high precision measurement requirements of micro-electronic connectors. Therefore this high precision measurement method can save the human resources and ensure the quality of micro-electronic connectors.
  Daqin Yun , Wei Feng , Hongcai Wu , Baoming Li , Xiaozheng Liu , Wenhui Yi , Junfen Qiang , Song Gao and Shaolin Yan
  Single-wall carbon nanotubes (SWNTs) have been covalently modified with poly[(2-methoxy,5-octoxy)1,4-phenylenevinylene] (MO-PPV) by in situ polymerization reaction to form a series of nanocomposites with well-controlled interfaces. The method provided a mean to disperse nanotubes uniformly and maximize the interfacial area at the same time. Absorption spectrum and electron microscopy imaging of the composite structure have been influenced by doped a small amount of functionalized SWNTs. Moreover, steady-state and time-resolved photoluminescence spectra quenched markedly by the introduction of internal polymer/nanotube junctions within the polymer matrix. Photovoltaic devices based on MO-PPV/SWNTs bulk heterojunctions showed much better in performance. The data suggested that such improvement was attributed to the bulk molecular heterojunctions intrinsic nanophase separation that resulted more efficient excitons separation, transportation and collection.
  Wei Feng , Hao Wu , Ling-Nga Chan and Mingjie Zhang
  PDZ domain-containing scaffold protein Par-3 is the central organizer of the evolutionarily conserved cell polarity-regulatory Par-3·Par-6·atypical protein kinase C complex. The PDZ domains of Par-3 have also been implicated as potential phosphoinositide signaling integrators, since its second PDZ domain binds to phosphoinositides, and the third PDZ interacts with phosphoinositide phosphatase PTEN. However, the molecular basis of Par-3/PTEN interaction is still poorly understood. Additionally, it is not known whether the regulatory function of PTEN in cell polarity is specifically mediated by its interaction with Par-3. The structures of Par-3 PDZ3 in both its free and PTEN tail peptide-bound forms determined in this work reveal that Par-3 PDZ3 binds to PTEN with two discrete binding sites: a canonical PDZ-ligand interaction site and a distal, opposite charge-charge interaction site. This distinct target recognition mechanism confers the interaction specificity of the Par-3·PTEN complex. We show that the Par-3 PDZ3-PTEN binding is required for the enrichment of PTEN at the junctional membranes of Madin-Darby canine kidney cells. Finally, we demonstrate that the junctional membrane-localized PTEN is specifically required for the polarization of Madin-Darby canine kidney cells. These results, together with earlier data, firmly establish that Par-3 functions as a scaffold in integrating phosphoinositide signaling events during cellular polarization.
 
 
 
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