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Articles by Watee Kongbuntad
Total Records ( 2 ) for Watee Kongbuntad
  Watee Kongbuntad , Kanokporn Saenphet , Chartchai Khanongnuch and Saisamorn Lumyong
  Xylanase derived from Thermoascus aurantiacus SL16W has characteristics of high activity, heat tolerance and exhibits the potential development for industrial feed enzyme. The objective of this study was to determine the toxic effect of crude xylanase on hematological and blood biochemistry in albino rats. Crude xylanase at doses of 750, 1,500 and 4,000 U kg-1 body weight (bw) were orally administered to rats for 120 days. Hematological and blood biochemistry levels were investigated in two periods (exposure and recovery). It was found that crude xylanase had no effect on rat`s body weight. SGOT levels of treated rats significantly decreased as compared to those of control group (p=<0.05), while SGPT levels were similar in all groups. BUN levels in treated groups were higher than those of controls in exposure period, but slightly lower in recovery period. However, Creatinine levels in treated groups were not different from control group. It was suggested from the results that crude xylanase is safe for using in animals feed industry.
  Watee Kongbuntad , Kanokporn Saenphet , Pairote Wongputtisin , Chatchai Khanongnuch and Saisamorn Lumyong
  The purpose of this study was to evaluate the toxicology of crude xylanase enzymes prepared from T. aurantiacus SL16W in male Albino rats. Sixty rats aged 6 weeks old were randomly distributed into 4 groups of 15 rats. The 1st group was the untreated control while the 2nd (400 U), 3rd (2000 U) and 4th (4000 U) groups received the crude xylanase enzyme at dose levels of 400, 2000 and 4000 unit/kg body weight/day, respectively. After treatmemt body weight, organ weight, hematology and plasma chemistry were examined. The results indicated that oral force-feeding of the crude xylanase enzyme did not affect the body and organ weight of the rats. Hemoglobin values in the 2000 U group and hematocrit values in the 2000 U group were slightly decreased compared to the control group. The levels of Blood Urea Nitrogen (BUN), creatinine, aspartate Aminotransferase (AST) and alanine Aminotransferase (ALP) were not significantly different between the groups except that the ALT of the 200 U was significantly lower than the control group.
 
 
 
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