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Articles by Wafaa Ibrahim
Total Records ( 3 ) for Wafaa Ibrahim
  Ehab M.M. Ali , Wafaa Ibrahim , Rana M. Ashraf and Ehab Tousson
  Background: Thyroid hormone has profound effects on the cardiovascular system and a regulatory effect on the rate of heme oxidation in the liver. Inducible isoform of heme oxygenase (HO-1) protects the heart and vasculature in pathological conditions. The present study aimed to identify the role of heme oxygenase in cardiac changes in thyroidectomized rats. Materials and Methods: Sixty male Wistar rats were equally divided into seven groups; the first and second groups were the control and sham operated groups, respectively while the 3rd and 4th groups were subjected to sham operation then treated with hemin (G3) and KTZ (G4). The 5th group (G5) was thyroidectomized group. The 6th and 7th groups were subjected to thyroidectomy then treated with hemin (G5) and KTZ (G6), respectively. Results: Hypothyroidism is documented by significant decrease in T3 accompanied with significant increase in serum TSH levels in thyroidectomized rats. The results obtained revealed that oxidative stress due to hypothyroidism has a detriment effect on cardiac tissue by depending on the result of cardiac Protein Carbonyl Content (PCC) as a marker of tissue damage and a negative significant correlation between cardiac PCC and serum Ferric Reducing Antioxidant Power (FRAP) as marker of Total Antioxidant Capacity (TAC). The Inducible Nitric Oxide Synthase (iNOS) activity in cardiac tissue showed significant decrease in thyroidectomized rats and its value was increased significantly upon treatment with hemin or ketoconazole (KTZ) as compared with sham operated rats. Treatment of thyroidectomized rats with hemin improves the intensity of iNOS immunoreactive cells demonstrating the recovery of some injury. Conclusion: There is a positive significant correlation between hepatic HO and iNOS in cardiac tissue. The paradoxical effect of both inducer and inhibitor of HO-1 on iNOS needs further studies. Also, to address this inquiry we need further investigation on time and dose-dependent effect of both inducer and inhibitor on cardiac tissue.
  Afrah Salama , Wafaa Ibrahim , Tarek El-Nimr , Mahmoud A. Abd El-Rahman and Ehab Tousson
  Background: Diabetes is a metabolic disorder characterized by resistance to the action of insulin, insufficient insulin secretion or both. The major clinical manifestation of the diabetic state is hyperglycemia. However, insulin deficiency and/or insulin resistance also are associated with disturbances in lipid and protein metabolism. Myrrh (from the stem of the Commiphora molmol tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis. The effect of myrrh on diabetes treatment is still unknown, therefore this study aimed to showing the effect of myrrh extract on diabetic rats. Materials and Methods: A total of 100 Albino rats were equally divided to 5 groups [control (G1), diabetic (G2), mirazid (G3), co-treated diabetic rats with amaryl (G4) and co-treated diabetic rats with mirazid (G5)]. Induction of Type II DM was carried out by intraperitoneal injection of 65 mg kg-1 b.wt. of streptozotocin. Many biochemical and physiological parameters were determined as changes in body weight gain percent, oral glucose tolerance test, insulin, insulin sensitivity percent, Liver glycogen content, fructosamine, liver and kidney functions. Also, total protein and total antioxidant capacity in serum, liver and in kidney homogenate in different groups under study were detected. Results: Myrrh extracts have hypoglycemic activity through decreasing blood glucose level, enhancing insulin secretion, increasing liver glycogen content and decreasing serum fructosamine. Myrrh extracts have antioxidant activity through increasing total antioxidant activity of serum and tissues, increasing total protein in tissues and enhancing liver enzyme AST and kidney function. Conclusion: This study concluded that Myrrh extracts have hypoglycemic activity and antioxidant activity through decreasing total antioxidant activity.
  Afrah F. Salama , Wafaa Ibrahim , Ehab Tousson , Saber Sakr , Ahmed Masoud , Mohamed A. Akela and Mahmoud A. Abd El-Rahman
  The author has withdrawn this article.
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