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| Articles
by
W.T. Artama |
Total Records (
1 ) for
W.T. Artama |
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Sri- Sudaryati
,
J.H.P. Sidadolog
,
Wihandoyo
,
W.T. Artama
and
D. Maharani
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Insulin-like growth factor binding protein 2 regulates a broad
spectrum of biological activities involved in growth, development and differentiation.
The current study was designed to investigate the associations of IGFBP2 gene
polymorphisms with the variance components and genetic parameters of four weekly
intervals of growth rate (0-4, 4-8, 8-12 weeks) of the Kampung chicken that
were evaluated with classical models of quantitative genetics. Thirty two females
and 16 males Kampung chicken were genotyped with IGFBP2 gene using PCR-RFLP
method. Retrieved 3 genotype (CC, CT and TT) and 2 alleles (C and T). The influence
of average effect of the C allele was greater than T allele on a 4-8 weeks intervals
of growth rate, meanwhile for the males turn into 0-4 and 8-12 weeks interval
growth rate. Ratio component additive and dominant deviation to each genotype
is always equal for each interval growth rate. Variance component from heterozygote
nearly zero when frequency of homozygote nearly equal and ratio variance dominance
were opposite to allele frequency. Narrow-sense heritability based on genetic
variance component of 0-4, 4-8 and 8-12 weeks interval growth rate for female
were 0.01, 0.47 and 0.87 while for male chicken were 0.94, 0.07 and 0.12, respectively.
It was concluded that IGFBP 2 gene association with growth rate on 4-8 and 8-12
weeks on females but in males only effect on growth rate on 0-4 weeks. |
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