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Articles by W.S. Koko
Total Records ( 2 ) for W.S. Koko
  Ehssan H.O. Moglad , Omer M. Abdalla , W.S. Koko and A.M. Saadabi
  In this study, eighty percent methanol and chloroform extracts of leaves and stems of Solanum nigrum were screened for in vitro anticancer activity using PC-3 human prostate cancer cell lines and Hela cervical cancer cells and cytotoxicity assays were performed using MTT assay and 3T3 NIH mouse embryo fibroblast cell line and CC-1, a rat Wistar hepatocyte cell line. All extracts in concentration 100 μg mL-1 showed anticancer activity in PC-3 and Hela and the highest percentage of growth inhibition obtained from stems methanol extracts on Hela 91.11% followed by leaves and stems methanol extracts (74.28 and 80.49, respectively) on PC-3. For cytotoxicity the result obtained indicate that all extracts had non-toxic effect on CC-I and 3T3 cell lines with IC50> 100 μg mL-1, except the leaves methanol extract showed the highest percentage of growth inhibition in 3T3 85.63 with IC50 17.37 μg mL-1. The results obtained indicate that Solanum nigrum leaves and stems methanol extracts have anticancer activity on prostate cancer, cervical cancer and have non-toxic effect on 3T3 and CC-1. This result supports the traditional use of Solanum nigrum for the treatment of cancer in different regions of the Sudan.
  Ehssan H.O. Moglad , Muddathir S. Alhassan , W.S. Koko and A.M. Saadabi
  The development of drug resistance as well as appearance of undesirable side effects of certain antibiotics has lead to the search for new antimicrobial agents mainly from plant extracts with the goal to discover new chemical structures. To overcome these disadvantages, the research was carried out to investigate the in-vitro antibacterial and antifungal activity of Cadaba farinose (Capparaceae), Solanum nigrum (Solanaceae), Senna occidentalis (Caesalpiniaceae) and Maerua oblongifolia (Capparaceae). Eighty percent Methanol and chloroform extracts of leaves of plants were screened for their antimicrobial activity against different pathogenic bacteria and fungi. These were Staphylococcus aureus, Bacillus subtilus, Escherichia coli, Salmonella typhi and Aspergillus niger and Candida albicans using the cup plate agar diffusion method. All methanol extracts exhibited inhibitory effects against all tested organisms with zones of inhibition ranging from 11-25 mm except the methanol extract of both parts of Maerua oblongifolia were active against Escherichia coli and Aspergillus niger. The results obtained from plants extracts were compared to some of the commercially used drugs. The Minimum Inhibitory Concentrations (MICs) of the most active extracts of these plants against standard bacteria and fungi were also determined and found that MICs a ranging between concentration 2.5-5 mg mL-1. All of the plants extracts were phytochemically screened and triterpenes, saponins and tannins were present in all of the methanolic extracts. Coumarins, sterols and triterpenes were found in all choloroform extracts, this finding indicated that these extracts of such plants promising antimicrobial agents.
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