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Articles by W.M. El-Deeb
Total Records ( 3 ) for W.M. El-Deeb
  W.M. El-Deeb and S.M. El-Bahr
  Background: Oxidative stress biomarkers and lipid profiles were used successfully as prognostic and diagnostic biomarkers of many animal diseases. However, their use in the diagnosis of ketosis in dairy cows at post-paturient period is not completely elucidated. Materials and Methods: Therefore, 25 cows suffered from ketosis at post-paturient period were used in the current study together with 20 healthy cows who served as a control. Blood samples were collected from diseased and healthy animals and the harvested serum were used for determination of oxidative stress biomarkers and the profiles of lipids, protein and enzymes. Results: The obtained results declared that, there was a significant (p≤0.05) increase in the levels of aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), non-esterified free fatty acids (NEFA), β-hydroxylbutyric acids (BHBA), malonaldehyde (MDA) and nitric oxide (NO) in dairy cows affected with ketosis compared to control. Conversely, a significant (p≤0.05) decrease in the levels of glucose, total cholesterol, cholesterol ester, free cholesterol, triacylglycerol (TAG), superoxide dismutase (SOD) and reduced glutathione (GSH) were detected in diseased cows compared to control. Serum BHBA, NEFA, MDA and NO levels were positively correlated with each other’s and inversely correlated with activity of SOD and GSH concentration in cows affected with ketosis. Conclusion: Oxidative stress biomarkers and lipid profiles could be used as promising biomarkers for ketosis in dairy cows at post-paturient period. The antioxidant therapy may useful in the treatment of ketosis in cows at post-paturient period.
  S.M. El-Bahr , W.M. El-Deeb and Aml S. Hashem
  Background and Objective: The investigation of antioxidant effect of fenugreek at molecular level in rats intoxicated with carbon tetrachloride (CCl4) are not completely elucidated. Therefore, the present study aimed to investigate the protective effect of aqueous extract of fenugreek (Trigonella foenum-graecum L.) against CCl4 hepatotoxicity in rats. Materials and Methods: Twenty four rats were allocated into four groups. Rats in groups 1-4 were injected with paraffin oil (control), subjected to oral administration of aqueous extract of fenugreek, injected with CCl4 diluted with paraffin oil 1:1 (1 mL kg–1 b.wt.) for 2 executive days and a combination of group 2 and 3, respectively. Results: Liver injury and oxidative stress were observed in untreated CCl4-intoxicated rats as reflected on histopathological picture, increase in hepatic transaminases, increase in lipid peroxidation (thiobarbituric acid reactive substances, TBARS), decrease of reduced glutathione (GSH) concentration, decrease in the activities of antioxidant enzymes namely catalase (CAT), total superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-s-transferase (GST) as well as down-regulation of gene expression of these enzymes compared to control. Administration of aqueous extract of fenugreek attenuated the detrimental effects of CCl4 via an up-regulation of gene expression and activities of antioxidant enzymes with increase in GSH concentration. Conclusion: Aqueous extract of fenugreek ameliorated CCl4-induced hepatotoxicity in rats. Aqueous extract of fenugreek exerted its protective effect against CCl4-induced toxicity by modulating the extent of lipid peroxidation and enhancing the antioxidant defence system at the activity and gene expression levels.
  T.A. Fouda , M.A. Youssef and W.M. El-Deeb
  From birth, the human being and animals are exposed to a continuous stream of microorganisms that have adverse effects on their body conditions and health status. In a global scale, there are many factors affecting the immune status such as systemic disorders, malnutrition, infectious diseases, deficiencies of minerals and trace element including copper, zinc, selenium and iron, protein-energy malnutrition, vitamins deficiency and fetal malnutrition. A total number of 20 diseased sheep, 1-2 years old from different localities had been subjected to this study. The selected animals were thoroughly examined and the results of physical and laboratory investigations were reported. The diseased animals showed the clinical signs of zinc deficiency mainly emaciation, alopecia and parakeratosis of the skin covering the vulva, anus, tail, head and ears. In addition ten clinically healthy sheep were served as control group. Lymphopenia with decreased activity of superoxide dismutase enzyme are characteristic for zinc deficiency. Monocytosis also recorded in such clinical cases, followed by significant decrease in monocytes % after zinc supplementation. In addition, decreased levels of serum total proteins, albumin, globulins and immunoglobulins in such cases were observed. The treatment with zinc improves cellular and humeral immunity. In addition, there was a significant (p<0.05) reduction in the levels of superoxide dismutase enzyme (0.4±0.02) in zinc-deficient sheep. The obtained results of laboratory investigations of zinc deficient sheep revealed that there was a significant reduction in the levels of zinc associated with non significant variations in the levels of copper. Concerning the leucocytic picture the results revealed that there was a significant (p<0.05) reduction in the total leucocytic count and a significant (p<0.05) decrease in lymphocyte % with a significant increase in monocytes % in cases of zinc deficiency when compared with their values in healthy animals. It could be concluded from this study that immune system is extremely affected by several factors. It is observed that micronutrient such as zinc is the major element affecting the immune status in sheep. This elemental deficiency adversely affects the cellular and humeral immune status in sheep.
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