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Articles by W.K.B.A. Owiredu
Total Records ( 7 ) for W.K.B.A. Owiredu
  E. Woode , N. Amidu , W.K.B.A. Owiredu , E. Boakye-Gyasi , C. Ansah and M. Duwiejua
  In the present study, the effect of an ethanolic extract of the roots of the plant in two animal models of depression the Forced Swimming Test (FST) and Tail Suspension Test (TST) has been reported. The extract (100-1000 mg kg-1; p.o.), dose-dependently reduced the duration of immobility in both the FST (ED50: 296.20 ± 53.97 mg kg-1) and TST (203.90 ± 39.01 mg kg-1).The effect of the extract was 20-50 times less potent than imipramime and fluoxetine which were used as standards. Pretreatment with α-methydopa (400 mg kg-1; 3 h; p.o.) attenuated the anti-immobility effects of imipramime but not SJE and fluoxetine. Similarly, pretreatment with reserpine (1 mg kg-1; 24 h; s.c.) abolished the effect of imipramime and partially the effects of SJE but not fluoxetine. A concomitant treatment with α-methyldopa and reserpine attenuated the effects of all but fluoxetine. The extract, imipramime and fluoxetine did not modify motor performance on the rotarod test at all doses tested. Putting all together, present results suggest that SJE has antidepressant-like effects in the model employed and may possibly exert its effects by modifying monoamine transport and/or metabolism.
  C.A. Turpin , L. Ahenkorah , W.K.B.A. Owiredu , E.F. Laing and N. Amidu
  The aim of this study was to determine the risk factors among Ghanaian women with Pregnancy-Induced Hypertension (PIH). Thirty women with preeclampsia, seventy with gestational hypertension and fifty normotensive pregnant women (controls) in the second half of pregnancy were recruited for this study. There was a significant increase in the prevalence of metabolic syndrome among the PIH subjects as compared to the normotensive pregnant women (controls) using the National Cholesterol Education Program (NCEPIII) and World Health Organisation criteria. Ghanaian women presenting with PIH are very prone to the development of the metabolic syndrome, thus the indices must be screened for during antenatal care.
  W.K.B.A. Owiredu , G. Amegatcher and N. Amidu
  This study evaluated the accuracy and precision associated with the use of three popular alternative-site blood glucose monitors, Accu-chek Advantage, Onetouch Horizon and Sensocard, using forearm venous blood samples and capillary blood samples. The study was conducted from January to March, 2009 at the Komfo Anokye Teaching Hospital, Kumasi. One hundred and ninety consenting subjects were included in the study. The blood glucose levels were analyzed on glucose meters; Accu-chek Advantage, Sensocard and Onetouch Horizon by finger stick, using amperometry Technology. At the same time venous blood glucose was analyzed using the WHO reference Glucose Oxidase Method (GOD). The mean value generated by the WHO reference method (7.91±0.35) was not significantly different (p = 0.2816) from that produced by the Accu-chek Advantage (8.46±0.36), Sensocard (7.72±0.35; p = 0.7028) and Onetouch Horizon (7.97±0.35; p = 0.9044). Bland-Altman analysis indicates that Onetouch Horizon and Accu-chek Advantage have the tendency of overestimating blood glucose with a bias of -0.1 and -0.5, respectively. Sensocard could under-estimate with a bias of 0.2. In terms of rating, while all the glucose meters gave precisions at about the same level (i.e., 1.0), Onetouch Horizon is generating the closest value to the reference method with a difference between mean of -0.06, followed by Sensocard of 0.19 and Accu-chek Advantage with a value of -0.55. The precision of the Accu-chek Advantage, Onetouch Horizon and Sensocard for blood glucose monitoring from about 3.1-33.3 mmol L-1 is good. However, the Accu-chek Advantage has the tendency to overestimate at the hypoglycaemic levels. The Accu-chek Advantage is capable of estimating both capillary and venous blood glucose to the same level of accuracy. The Onetouch Horizon and Sensocard are however incapable of efficiently estimating venous blood glucose.
  C. Ansah , E.A. Mfoafo , E. Woode , C. Opoku-Okrah and W.K.B.A. Owiredu
  In this study, we evaluated the aqueous extract of the roots of Cryptolepis sanguinolenta (Periplocaceae), an anti-malarial herb in the West African sub-region for possible toxicity in rodents. Administration of cryptolepis (10-1000 mg kg-1) daily for two weeks did not cause significant changes in most of the haematological parameters assessed. However, the MCV reduced from a vehicle-treated value of 63.1 ± 0.6 to 58.1 ± 0.9 g dL-1 at a dose of 10 mg kg-1, which reflected in an increased MCHC (27.8 ± 0.3 to 30.5 ± 0.3 g dL-1), since the Hb concentration remained unchanged. Serum transaminase levels did not change significantly suggesting a limited effect on the liver. Administration of the extract (50-1000 mg kg-1, p.o.) 30 min before pentobarbitone (50 mg kg-1, i.p.) caused a dose-dependent prolongation of the rat sleeping time from 66.6 ± 8.1 min (vehicle-treated control) to 266.5 ± 7.0 min (1000 mg kg-1). Similarly, daily treatment with the extract (50-1000 mg kg-1) for 2 weeks prolonged the sleeping time from 155 ± 28.4 to 292.8 ± 28.7 min. This effect appeared to be CNS-related rather than an enzymatic as reflected in a decreased locomotor activity (19.4 ± 1.5 to 1.8 ± 0.8 min-1) at a dose of 500 mg kg-1 body weight. All together, our results suggest that Cryptolepis could synergize with hypno-sedatives or other CNS depressants and therefore caution needs to be taken in the concomitant administration of Cryptolepis and other CNS depressants.
  M.T. Agyei-Frempong , F.V.K. Titty , W.K.B.A. Owiredu and B.A. Eghan
  This study investigate the occurrence and the prevalence of autoantibodies and the metabolic characteristics of autoimmune and antibody-negative type 2, diabetes in recently diagnosed diabetes mellitus patients in Kumasi, Ghana. This study involved a total of 120 recently diagnosed (< 1 year) Ghanaian diabetes mellitus patients (17 insulin-requiring and 103 non insulin-requiring) and 60 controls. A standardized questionnaire was used. Blood pressure and anthropometric measurements were taken. Fasting glucose, lipid and lipoprotein concentrations were measured by enzymatic methods and HbA1C levels by agglutination test. Serum insulin level and autoantibodies (ICA, GAD ab and IAA) were analyzed by enzyme-linked immunosorbent assay (ELISA). Out of the 17 insulin-requiring, six were positive for either GAD ab or ICA or both. Out of the 103 non insulin-requiring, 16.5% were positive for ICA and /or GAD ab and/or IAA. The prevalence of Latent Auto-immune Diabetes of Adults (LADA) in the non-insulin requiring and in the total diabetic patients, were 13.5 and 11.7%, respectively. The prevalence of autoimmune type 1 diabetes in the studied population was 7.5% and that of autoimmune diabetes in the total diabetic population was 19.2%. Autoimmune and autoantibody-negative type 2, diabetes did not differ (p = ns) in the mean values of clinical and metabolic parameters, except hypertension, central obesity and HbA1C values. Autoimmune diabetes occurs in recently diagnosed diabetic patients in Ghana at prevalence comparable to that in developed countries. Both ICA and GAD ab tests are required to identify autoimmune diabetes.
  W.K.B.A. Owiredu , S. Donkor , B. Wiafe Addai and N. Amidu
  The purpose of this study was to carry out a comparative study to investigate the effect of lipid profile, oestradiol and obesity on the risk of a woman developing breast cancer. This study was carried out at the Komfo Anokye Teaching Hospital (KATH), Peace and Love Hospital, Oduom, Kumasi and Redeemed Clinic, Nima, Accra between May 2002 and March 2003. In this study, 200 consented women comprising 100 breast cancer patients (43 pre- and 57 post-menopausal) and 100 controls (45 pre- and 55 post-menopausal) with similar age range (25 to 80 years) were assessed for lipid profile, oestradiol and BMI. There was a significant increase in Body Mass Index (BMI) (p = 0.011), Total Cholesterol (TC) (p<0.001), triglyceride (p = 0.026) and low density lipoprotein (LDL-cholesterol) (p = 0.001) of the breast cancer patients compared to the controls. With the exception of oestradiol (EST) that decreased, the lipid profile generally increased with age in both subjects and controls with the subjects having a much higher value than the corresponding control. There was also a significant positive correlation between BMI and TC (r2 = 0.022; p = 0.002) and also between BMI and LDL-cholesterol (r2 = 0.031; p = 0.0003). Apart from EST and LDL-cholesterol that were increased significantly only in the postmenopausal phase in comparison to the controls, BMI, TC and TG were increased in both pre-menopausal and post menopausal phases with HDL-cholesterol remaining unchanged. This study confirms the association between dyslipidaemia, BMI and increased breast cancer risk.
  W.K.B.A. Owiredu , J. Appiah-Poku , F. Adusei-Poku , N. Amidu and Y. Osei
  This study examined possible association of fasting glucose, and lipid abnormalities in psychiatric patients on conventional antipsychotic medications. A total of 305 subjects were used for the study, comprising 203 clinically diagnosed psychiatric patients and 102 non-psychiatric subjects used as control at the psychiatric clinic at Komfo Anokye Teaching Hospital (KATH). Questionnaires were administered, blood pressure and anthropometric measurements undertaken. Fasting blood samples were taken for glucose and total cholesterol. The patients included those treated with conventional antipsychotic agents. It was noted, that there were higher rates of diabetes (22.17%) and lipid abnormalities (42.43%) with lower rate of hypertension (5.91%) and obesity (5.91%) across the sample as compared to control. This finding suggests that the high prevalence of diabetes and lipid abnormalities, in a young, psychiatrically ill population makes the case for aggressive screening.
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