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Articles by W.E. Olooto
Total Records ( 3 ) for W.E. Olooto
  B.A Salau , A.O. Ketiku , O.L. Adebayo , W.E. Olooto , E.O. Ajani and O. Osilesi
  The involvement of sucrose and its amount in the causation of cardiovascular disease is still controversial and inconclusive. The two latest reports of WHO/FAO and Institute of Medicine of Food and Nutritional Board (IOM of FNB) on optimal level of sucrose consumption are at least contradictory; therefore the need to clarify the effect of different concentrations of sucrose consumption on cardiovascular disease risk factor is expedient. Effect of sucrose consumption was assessed on twenty four male albino rats, four to six weeks old, 48-65 g, divided into five groups: G1 (control), G2 (10% energy supply from sucrose), G3 (20% energy supply from sucrose), G4 (30% energy supply from sucrose). The following parameters were determined: red blood cell count, white blood cell count, packed cell volume, blood and plasma viscosities; fibrinogen level and erythrocyte sedimentation rate. Analyses revealed that inclusion of sucrose at concentration of 20% energy supply significantly increased (p<0.05) blood viscosity by 97.59%, plasma viscosity 16.48%, erythrocyte sedimentation rate 40.00%, plasma fibrinogen13.63% and white blood cell count 6.59%, while no significant effect (p>0.05) was observed on red blood cell count and packed cell volume. The study revealed that consumption of sucrose at twenty percent energy supply increased some selected haematological and haemorrheological parameters associated with cardiovascular disease.
  B.A. Salau , W.E. Olooto , O.L. Adebayo , E.O. Ajani , K.T. Odufuwa and J.O. Olowookere
  Effects of various concentrations of sucrose diet were assessed on thirty weaning male albino rats divided randomly into five equal groups as follows: G1 (baseline group); G2 (control group given rat chow only); G3, G4 and G5 (groups with energy supply from sucrose at 10, 20 and 30%, respectively). The four groups were fed for twelve weeks and then fasted overnight. They were then anaesthetized with diethyl ether and venous blood was collected using cardio puncture method. Plasma was collected by centrifugation and total plasma cholesterol, HDL cholesterol and serum Triglycerides were assayed using Randox enzymatic kit while VLDL cholesterol, LDL cholesterol, Atherogenic index and coronary risk indices were calculated. Sucrose diet increased energy density. It also increased significantly (p<0.05). Plasma total cholesterol, LDL cholesterol, VLDL cholesterol, Triglycerides, Atherogenic and Coronary risk indices while it decreased HDL cholesterol. Present results indicated that sucrose diet at present level of consumption (about 25% energy supply) elevated cardiovascular risk factors in male albino rats and may predispose one to cardiovascular diseases.
  W.E. Olooto , A.A. Amballi , A.O. Mosuro , A.A. Adeleye and T.A. Banjo
  Preeclampsia is majorly a clinical disorder of pregnancy (occurring after 20 weeks of gestation in previously normotensive women) with unknown pathophysiology and associated organ dysfunctions. This study determined the biochemical changes associated with preeclampsia in the serum and urine. Blood pressure, serum total protein, albumin, creatinine and aspartate transaminase level and urinary protein were assessed (using standard methods) in 105 primigravidae. There was no significant difference (p>0.05) in booking systolic and diastolic blood pressure but significant differences (p<0.05) existed between systolic and diastolic blood pressure of preeclamptic patients and controls. Also, 9 (10.1%) out of 89 that completed the study had preeclampsia, 3 (3.4%) had pregnancy induced hypertension only while 77 (86.5%) remained normotensive. Serum total protein (50.11±3.33), albumin (22.67±1.22) and globulin (27.44±3.78) levels were found to be significantly low (p< 0.05) in preeclampsia as compared to the control (69.33±1.5, 37.78±2.59 and 31.56±3.25, respectively) while serum Aspartate Transaminase (27.11±4.73) and creatinine (90.44±1.74) levels were found to be significantly higher (p<0.05) in preeclampsia than controls (8.56±3.17 and 62.67±1.58, respectively). The outcome of the pregnancy shows that two patients had abortion, one had preterm delivery and one had intrapartum eclampsia. Conclusively, results of hematologic and biochemical parameters should be considered for the timing delivery of women with pre-eclampsia as indicated by high levels of AST, blood pressure greater than or equal to 140/90 mmHg and proteinuria of ≥300 mg/24 h.
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