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Articles by W. Wang
Total Records ( 5 ) for W. Wang
  P Ouyang , Y Jiang , H. M Doan , L Xie , D Vasquez , R Welti , X Su , N Lu , B Herndon , S. S Yang , R Jeannotte and W. Wang
 

Exercise has been linked to a reduced cancer risk in animal models. However, the underlying mechanisms are unclear. This study assessed the effect of exercise with dietary consideration on the phospholipid profile in 12-O-tetradecanoylphorbol-13-acetate (TPA)–induced mouse skin tissues. CD-1 mice were randomly assigned to one of the three groups: ad libitum–fed sedentary control; ad libitum–fed treadmill exercise at 13.4 m/min for 60 min/d, 5 d/wk (Ex+AL); and treadmill-exercised but pair-fed with the same amount as the control (Ex+PF). After 14 weeks, Ex+PF but not Ex+AL mice showed ~25% decrease in both body weight and body fat when compared with the controls. Of the total 338 phospholipids determined by electrospray ionization–tandem mass spectrometry, 57 were significantly changed, and 25 species could distinguish effects of exercise and diet treatments in a stepwise discriminant analysis. A 36% to 75% decrease of phosphatidylinositol (PI) levels in Ex+PF mice occurred along with a significant reduction of PI 3-kinase in TPA-induced skin epidermis, as measured by both Western blotting and immunohistochemistry. In addition, ~2-fold increase of the long-chain polyunsaturated fatty acids, docosahexaenoic and docosapentaenoic acids, in phosphatidylcholines, phosphatidylethanolamines, and lysophosphatidylethanolamines was observed in the Ex+PF group. Microarray analysis indicated that the expression of fatty acid elongase-1 increased. Taken together, these data indicate that exercise with controlled dietary intake, but not exercise alone, significantly reduced body weight and body fat as well as modified the phospholipid profile, which may contribute to cancer prevention by reducing TPA-induced PI 3-kinase and by enhancing -3 fatty acid elongation. Cancer Prev Res; 3(4); 466–77

  W. Gu , Y. Huang , Y. Zhang , J. Hong , Y. Liu , W. Zhan , G. Ning and W. Wang
 

Aim

To compare the carotid intima-media thickness in patients with newly diagnosed Type 1 or Type 2 diabetes ranging from 14 to 30 years of age.

Methods

Demographic, anthropometric and laboratory data were obtained from 404 adolescents and young adults (103 subjects with Type 1 diabetes, 94 with Type 2 diabetes, 153 obese subjects and 54 normal control subjects). Carotid intima-media thickness was assessed based on Doppler ultrasound examination and compared among the four groups.

Results

Our data showed significant increases in carotid intima-media thickness in subjects with Type 1 diabetes, Type 2 diabetes and obese subjects compared with the control subjects, with those in the group with Type 2 diabetes demonstrating the greatest change (P < 0.001). Age, BMI, percentage of fat, waist-hip ratio and total triglycerides were significantly correlated with both common and internal carotid intima-media thickness segments. From a stepwise multiple linear regression model, the independent determinants of common carotid intima-media thickness were age, BMI, HbA1c and HDL cholesterol (adjusted R2 = 0.152, P < 0.001). After adjustment for age, sex and HbA1c, the odds ratio for increased carotid intima-media thickness was 1.67 (95% CI 1.19-2.33, P = 0.003) for obese subjects, 2.38 (95% CI 1.59-9.47, P = 0.001) for subjects with Type 1 diabetes and 3.93 (95% CI 1.90-6.07, P = 0001) for subjects with Type 2 diabetes compared with the control subjects.

Conclusions

Compared with young control subjects, we found significant increases in carotid intima-media thickness in patients with newly diagnosed Type 1 diabetes and Type 2 diabetes, with patients with Type 2 diabetes showing greater carotid intima-media thickness. Traditional cardiovascular risk factors, such as obesity, dyslipidaemia, hypertension and hyperglycaemia, could cause vessel changes even in adolescents and young adults.

  M. Shakir and W. Wang
  Power conservation is an issue which has to be primarily considered in wireless sensor networks. Since we have the limitation of battery life so an appropriate transmit power has to be chosen while guaranteeing the maximal connectivity at the same time. It is in our best interest to have each node transmit at lowest possible power thus prolonging the network lifetime and preserving the connectivity. So this study investigate the most optimum transmit power while considering the data rates and how densely the nodes are deployed. The effects of the interference powers have to be minimized by reaching towards the minimal transmit power. We have worked out on the interference powers introduced due to different ways of deployments of wireless sensor networks over a certain area and we used the graphical approach to look at the effects of distance from the central receiving nodes and the varying densities on the BER. We have also investigated the phenomena through simulations and the main aim being to optimize the performance of sensor networks by observing their behavior in various regularly placed deployments.
  W. Wang , L. Wang , J.N. Li and M. Zhang
  Nine bacterial strains (LA1, LA2, LA4, JA1, CA3, CA4, BA1, BA18 and EA9) were isolated from different aquaculture animals with haemorrhagic septicemia and then they were identified as A. hydrophila (LA4, JA1, CA3 and BA1), A. sobria (LA1 and EA9), A. caviae (BA18) and A. veronii (CA4 and LA2), respectively by morphological and biochemical characterization. All isolates were found to be pathogenic to experimental zebrafish (Danio rerio) by artificial infection test. The outer membrane protein Aha1 is a major adhesin of A. hydrophila and also highly conserved in different serotypes of A. hydrophila. In order to ascertain the conservation of aha1 protein among mesophilic motile aeromonads, full length aha1 gene from all isolates was detected, cloned and sequenced. As the results show, the aha1 genes were amplified in all strains and the ORF size of the aha1 gene from A. hydrophila and other phenotypic species of aeromonas isolates was 1,068 and 1,038 bp, respectively. Four Anhui A. hydrophila isolates and six A. hydrophila reference strains formed a cluster together with 91.4-99.7% nucleotide identity and 91.9-99.7% amino acid identity of the aha1 gene. Five Anhui other phenotypic species isolates formed another cluster, they shared 79.5-81.1% nucleotide identity and 79.6-81.6% amino acid identity of the aha1 gene compared with A. hydrophila and the major sequence variations were observed between amino acids 85-134, 176- 227, 243-263, 280-295 and 321-336.
  M. Li , G. Ji , F. Feng , W. Song , R. Ling , D. Chen , X. Liu , J. Li , H. Shi , W. Wang and H. Zhang
 

Objective: We summarized our experience of living-related small bowel transplantation and postoperative management of 3 patients with short gut syndrome.

Methods: Patient #1, an 18-year-old boy, received a 150-cm segment of distal ileum with a vascular pedicle of distal superior mesenteric artery and vein, which was donated by his father. Patient #2, a 15-year-old boy, received a 160-cm graft of distal ileum from his mother. Patient #3, a 17-year-old boy, received a 170-cm graft of distal ileum from his father. The graft artery and vein were anastomosed to the recipient infrarenal aorta and vena cava, respectively, in end-to-side fashion using 7/0 Prolene suture. Intestinal continuity was restored by anastomosis of proximal end of the graft to the recipients' own proximal jejunum, the distal end was left open as a stoma. The recipient distal gut was anastomosed to the distal end of the graft. All 3 recipients were given FK506 (tacrolimus) regularly combined with periodic mycophenolate mofetil. In cases of acute rejection, large doses of steroids were administered to the recipients.

Results: The recipients and donors had fairly unremarkable postoperative courses. So far, patient #1 has survived for 7 years and 6 months with a well-functioning graft and without requirement for total parenteral nutrition (TPN) support. His body weight increased 20 kg and of his life quality has dramatically improved. Patient #2, however, died of acute rejection with fatal sepsis at 5 months after transplantation. Patient #3 has survived for 3 years and 8 months enjoying a normal life. Postoperative recovery of all 3 donors was unremarkable. They were discharged 12 days after surgery without complications.

Conclusion: Outcomes of the implantation using the distal ileum as a graft in living-related small bowel transplantation have been satisfactory for both recipients and donors. It is feasible to anastomose the graft artery and vein to the recipient infrarenal aorta and vena cava. The intestinal continuity can be restored by a 1-stage strategy with minimal risk to the recipient. Appropriate application and adjustment of immune suppressors are crucial for the recipients to experience high-quality lives.
 
 
 
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