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Articles by W. Jin
Total Records ( 4 ) for W. Jin
  L Chen , S Xu , X Zeng , J Li , W Yin , Y Chen , Z Shao and W. Jin

Chemokine C-X-C motif ligand 12 (CXCL12) is a potent chemotactic and angiogenic factor that has been proposed to play a role in organ-specific metastasis and angiogenic activity in several malignancies. In this study, we found that the overexpression of c-myb could elevate CXCL12 mRNA level and CXCL12 promoter activity in human T47D and MCF-7 breast cancer cells. Chromatin immunoprecipitation assay demonstrated that c-myb could bind to the CXCL12 promoter in the cells transfected with c-myb expression vector. c-myb siRNA attenuated CXCL12 promoter activity and the binding of c-myb to the CXCL12 promoter in T47D and MCF-7 cells. These results indicated that c-myb could activate CXCL12 promoter transcription.

  Y Zhao , J Liu , Q Hong , C Yang , L Chen , Y Chen , Q Wang , K Zhao and W. Jin

Overexpression of multidrug resistance 1 (MDR1) in cancer remains one of the major causes for the failure of chemotherapy. In the present study, we found that MyoD and PEA3 could activate P-glycoprotein (P-gp) expression in SGC7901 cells. Knockdown of MyoD and PEA3 attenuated MDR1 expression and increased the sensitivity of multidrug resistant cancer cells to cytotoxic drugs that were transported by P-gp in SGC7901/VCR cells. MyoD or PEA3 could bind to the E-box and PEA3 sites on the MDR1 promoter and activate its transcription. The regulation of MDR1 expression by MyoD and PEA3 may provide potential ways to overcome MDR in cancer treatment.

  Y.L. Hoo , W. Jin , L. Xiao , J. Ju and H.L. Ho
  Refractive index (RI) sensing based on the anti-guiding property of a depressed-index core photonic crystal fiber (PCF) is studied. A new type of RI sensor is formed by adding a hole to the core of a conventional index guiding PCF for the purpose of measurand filling and the depressed-index core formation. The dependencies of measurement resolution and dynamic range on the structural parameters of the RI sensor are investigated. RI sensors filled with the measurand covering a refractive index range from 1.328 to 1.445 are numerically simulated. Simulation results show that the measurement resolution from 9.32 x 10–7 to 1.23 x 10–7 can be achieved by means of wavelength measurement with an optical spectrum analyzer with 0.01 nm resolution. Also, problem caused by the existence of the photonic bandgap (PBG) mode which may influence the feasibility of the RI sensing mechanism is considered.
  Y.L. Hoo , W. Jin , J. Ju and H.L. Ho
  A depressed-index core photonic crystal fiber (PCF) was numerically analyzed for gas sensing application. The dependence of relative sensitivity, effective mode area, confinement loss, and bend loss on the fiber parameters as well as wavelength are investigated. Lowering the refractive index of core reduces the index contrast between the core and the cladding weakens the index-guidance of the fiber, and enhances the relative sensitivity and the mode area simultaneously. Relative sensitivity and effective mode area increase with the cladding background index, especially in the short wavelength region, which are opposite to that in a conventional PCF. The enhancements of the relative sensitivity and the normalized effective mode area are more than 3700% (from 0.0065 to 0.25) and 680% (from 3.85 to 30), respectively, as compared with that of the non-depressed-index core PCF.
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