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Articles by W. Huang
Total Records ( 3 ) for W. Huang
  T.S. Xu , X.L. Liu , W. Huang and S.S. Hou
  Traditional force feed technology produced excessive fat ducks and could not meet the wide range needs. This study studied the possibility of breeding muscular Pekin duck. Data collection was performed in an experimental Pekin duck line. At 7 weeks of age, 1,985 ducks were selected according to their pedigree to measure the traits studied in this study. Single and multiple trait analyses were used to estimated heritability and variance components by restricted maximum likelihood. Heritability estimation of Body Weight (BW), Keel Length (KL), Breast Breadth (BB) and Breast Meat Thickness (BMT) were moderate to high (0.20-0.53). The heritability for Breast Muscle Weight (BMW) and Breast Meat Percentage (BMP) were 0.50 and 0.47, respectively suggesting an increase of breast meat development could be achieved by selection. The heritability of Abdominal Fat Weight (AFW), Abdominal Fat Percentage (AFP), Leg Muscle Weight (LMW) and Leg Muscle Percentage (LMP) were 0.23, 0.32, 0.38 and 0.16, respectively. The genetic correlation between BW and those of BMW and BMP were 0.74 and 0.25. Which suggest that BMP, not BMW may be a selection criterion for muscular Pekin duck. The genetic correlation between BMP and those of KL, BB and BMT were 0.69, 0.69 and 0.71, respectively. The genetic correlation between BMP and AFP was -0.03, therefore body size traits could be used as the selection index for improving the BMP and selecting for higher BMP should not decrease the leanness. In conclusion, higher BMP and lower AFP Pekin duck could be achieved.
  T.S. Xu , L.H. Gu , X.H. Zhang , W. Huang , B.G. Ye , X.L. Liu and S.S. Hou
  Breast Muscle (BM) and Leg Muscle (LM) in Pekin duck belong to different types. However, myofiber differences of BM and LMcle and relationship between myofiber development with the expressions of IGF-1 and FoxO3 are not clear. The difference of BM and LM fibres was investigated and relationship between the two gene expressions and myofiber development was explored at D2 (the 2nd day), W2 (the 2nd week), W4, W6. Results showed the development of BM and LM fibres were different as the Relative Growth Areas (RGAs) of BM and LM fibres reached their maximum values at W4-W6 and W2-W4, respectively. The expression of IGF-1 peaked while that of FoxO3 bottomed, at W6 and W2 in BM and LM, respectively. The results of this study could provide basic insight into the skeletal muscle development, the expressions of IGF-1 and FoxO3 and the association between the two aspects.
  Z Meng , Y Wang , L Wang , W Jin , N Liu , H Pan , L Liu , L Wagman , B. M Forman and W. Huang

Liver repair is key to resuming homeostasis and preventing fibrogenesis as well as other liver diseases. Farnesoid X receptor (FXR, NR1H4) is an emerging liver metabolic regulator and cell protector. Here we show that FXR is essential to promote liver repair after carbon tetrachloride (CCl4)-induced injury. Expression of hepatic FXR in wild-type mice was strongly suppressed by CCl4 treatment, and bile acid homeostasis was disrupted. Liver injury was induced in both wild-type and FXR–/– mice by CCl4, but FXR–/– mice had more severe defects in liver repair than wild-type mice. FXR–/– livers had a decreased peak of regenerative DNA synthesis and reduced induction of genes involved in liver regeneration. Moreover, FXR–/– mice displayed increased mortality and enhanced hepatocyte deaths. During the early stages of liver repair after CCl4 treatment, we observed overproduction of TNF and a strong decrease of phosphorylation and DNA-binding activity of signal transducer and activator of transcription 3 in livers from FXR–/– mice. Exogenous expression of a constitutively active signal transducer and activator of transcription 3 protein in FXR–/– liver effectively reduced hepatocyte death and liver injury after CCl4 treatment. These results suggest that FXR is required to regulate normal liver repair by promoting regeneration and preventing cell death.

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