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Articles by W. Hu
Total Records ( 5 ) for W. Hu
  Y. Liu , S. Q. Li , S. J. Yang , W. Hu and X. P. Chen
  Carbon dioxide flux from the soil to the atmosphere is an important component of terrestrial C cycling, and accurate estimates of CO2-C fluxes are crucial for estimating C budgets. A field study was conducted (i) to examine the diurnal and seasonal soil CO2 flux pattern in spring maize fields on the Loess Plateau, and (ii) to determine the effects of soil characteristics affected by various cultivation practices on CO2 flux from the soil surface to the atmosphere. Soil surface CO2 flux was determined with an LI-8100 Automated Soil Flux System, and related environmental factors were also measured, including near-ground air temperature and relative humidity, soil moisture (0-15 cm), soil temperature (at depths of 5, 10, 15, and 20 cm), and leaf area index. Diurnal soil CO2 flux showed a single peak between 12-00 h and 16-00 h, and reached a minimum in the early morning, at about 4-00 h. During the crop's growing season, soil CO2 flux increased during the rapid vegetative growth stages, reached its maximum during the peak reproductive stages, and then declined as the plants senesced. Time series analysis showed that the temporal dynamics of the CO2 flux were more closely related to air temperature than to soil temperature; this may be because a substantial portion of the CO2 originated from surface residues. The time-averaged mean soil CO2 flux for different cultivation practices over the growing season was ranked as follows: plastic film mulching (3.980 µmol m-2s-1) > corn straw mulching (3.464 µmol m-2s-1) > supplementary irrigating (3.157 µmol m-2s-1) > rain-fed (2.371 µmol m-2s-1) > bare ground (1.934 µmol m-2s-1). Different cultivation practices affected plant and microbial activities, and soil hydrothermal conditions, and caused different patterns of soil surface CO2 flux in spring maize fields on the Loess Plateau.
  J. Lu , C. Hu , W. Hu , R. Zhang , C. Wang , W. Qin , W. Yu and K. Xiang
  Aims  Electrocardiographic ventricular repolarization QT parameters are independent risk factors for cardiovascular events and sudden cardiac death in diabetic patients. The aim of the study was to investigate the association of polymorphisms of the nitric oxide synthase 1 adaptor protein (NOS1AP) gene with QT interval in Chinese subjects with or without Type 2 diabetes.

Methods  Three single nucleotide polymorphisms (SNPs) (rs10494366, rs12143842 and rs12029454) were genotyped in 1240 Type 2 diabetic patients (631 men and 609 women) and 1196 normal controls (433 men and 763 women). Individuals with overt diseases other than diabetes were excluded. Heart-rate corrected QT interval (QTc) was determined by standard 12-lead ECG and Bazett formula. Sex-pooled analysis and sex-specific analysis for genotype-phenotype association were both conducted.

Results  In the diabetic group, the rs12143842 T allele was associated with a 3.87-ms (= 0.014, empirical = 0.039) increase in QTc duration for each additional allele copy, while rs10494366 and rs12029454 exhibited no significant association with QTc. We found no evidence of association for the three SNPs in subjects with normal glucose regulation. No significant SNP-gender and -diabetes affection interaction was observed.

Conclusions  The genetic variant rs12143842 in NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes. Future studies in different populations are needed to validate this finding and to evaluate the impact of NOS1AP variants on cardiovascular events and sudden cardiac death in diabetic patients.

  W. Yu , F. Zhang , W. Hu , R. Zhang , C. Wang , J. Lu , F. Jiang , S. Tang , D. Peng , M. Chen , Y. Bao , K. Xiang , C. Hu and W. Jia
 

Aim

There is a close link between electrocardiographic ventricular repolarization QT parameters and Type 2 diabetes. The aim of the present study was to assess the effects of QT-related and diabetes-related variants in KCNQ1 on QT interval in a Chinese population.

Methods

We recruited 2415 patients with Type 2 diabetes and 1163 subjects with normal glucose regulation in the present study. QT interval was obtained and the heart rate-corrected QT interval (QTc) was calculated using Bazett's formula. Four single nucleotide polymorphisms in KCNQ1 were selected (rs12296050, rs12576239, rs2237892 and rs2237895) and genotyped.

Results

 In participants with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46-ms QTc prolongation under an additive model (P = 0.0109, empirical P = 0.0498). In patients with Type 2 diabetes, we did not find any association for the single nucleotide polymorphisms.

Conclusions

Our findings indicate that KCNQ1 is associated with QT interval in a Chinese population with normal glucose regulation.

  C. Ju , B. Xu , Y. Lu , X.J. Mo , T. Zhang , S.B Chen , F. Liu , S.J. Cui , W. Liu , J.H. Chen , Z. Feng , J.X. Peng and W. Hu
  Schistosomiasis ranks as the second most serious parasitic disease worldwide after malaria. More than 250 million people are infected with schistosomes in the tropics or subtropics. The treatment and control of schistosomiasis which is a major neglected tropical parasitic disease, depends almost exclusively on chemotherapy with Praziquantel (PZQ). Current serologic diagnostic assays have shown that schistosome specific antibodies in human serum may remain for at least 1 year after cure. Repeated administration of PZQ for a long time might induce drug resistance to the parasite which is a big challenge for strategizing for the prevention and control of schistosomiasis. As schistosome eggs represent the most pathogenic form causing the disease, it is essential to determine if and how the level of antibodies against schistosome Soluble Egg Antigens (SEA) is affected by PZQ treatment. In this study, researchers carried out an immunomic analysis to profile Schistosoma japonicum SEA reacting with pooled human serum samples of pre and post treatment with PZQ by two dimensional electrophoresis combined with Western blotting. A total of 67 protein spots that were serologically recognized by serum samples were successfully subjected to mass spectrometric analysis. Of them, 37 different characterized proteins were successfully identified. Furthermore, of 67 protein spots, the reactivity of 49 protein spots to sera was reduced 20 weeks after PZQ treatment whereas only 5 spots showed increases in the intensity of recognition by post treatment sera. The present study suggested that chemotherapy with PZQ mainly affects the intensity of serological recognition of S. japonicum SEA. The immunomic proteins that were identified may facilitate a better understanding of the egg induced pathogenesis of schistosomiasis and host-parasite interplay and may provide potential targets for the diagnosis and evaluation of treatment for the disease as well.
  F Li , D. Y Hu , S Liu , S Mahavadi , W Yen , K. S Murthy , K Khalili and W. Hu
 

Regulator of G protein signaling 4 (RGS4) regulates the strength and duration of G protein signaling and plays an important role in smooth muscle contraction, cardiac development, and psychiatric disorders. Little is known about the posttranscriptional regulation of RGS4 expression. We cloned the full-length cDNA of rabbit RGS4, which contains a long 3'-untranslated region (UTR) with several AU-rich elements (AREs). We determined whether RGS4 mRNA stability is mediated by the RNA-binding protein human antigen R (HuR) and contributes to IL-1β-induced upregulation of RGS4 expression. We show that IL-1β treatment in colonic smooth muscle cells doubled the half-life of RGS4 mRNA. Addition of RGS4 3'-UTR to the downstream of Renilla luciferase reporter induced dramatic reduction in the enzyme activity and mRNA expression of luciferase, which was attenuated by the site-directed mutation of the two 3'-most ARE sites. IL-1β increased luciferase mRNA stability in a UTR-dependent manner. Knockdown of HuR significantly aggravated UTR-mediated instability of luciferase and inhibited IL-1β-induced upregulation of RGS4 mRNA. In addition, IL-1β increased cytosolic translocation and RGS4 mRNA binding of HuR. These findings suggest that 3'-most ARE sites within RGS4 3'-UTR are essential for the instability of RGS4 mRNA and IL-1β promotes the stability of RGS4 mRNA through HuR.

 
 
 
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