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About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were
used in this study over a 20 day period. They were allocated randomly into 4
groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was
control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic
ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate
film with therapeutic ultrasound. On application, the collagen-calcium alginate
film with therapeutic ultrasound was well accepted by the animals without any
adverse reaction. Mean percentage of wound contraction were significantly better
in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium
alginate film with therapeutic ultrasound treated group as compared to the other
groups. Collagen is a biocompatible protein that does not interfere with the
body’s normal immunologic response and can be used in non-healing chronic
wounds which require a trigger to stimulate the normal healing process. In extensive
wounds when there is lack of autologous tissue, biomaterials like collagen-calcium
alginate may be beneficial and can be used.
