Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by W Ohashi
Total Records ( 1 ) for W Ohashi
  C Kitabayashi , T Fukada , M Kanamoto , W Ohashi , S Hojyo , T Atsumi , N Ueda , I Azuma , H Hirota , M Murakami and T. Hirano

Zinc (Zn) is an essential trace metal required by many enzymes and transcription factors for their activity or the maintenance of their structure. Zn has a variety of effects in the immune responses and inflammation, although it has not been well known how Zn affects these reactions on the molecular basis. We here showed that Zn suppresses Th17-mediated autoimmune diseases at lest in part by inhibiting the development of Th17 cells via attenuating STAT3 activation. In mice injected with type II collagen to induce arthritis, Zn treatment inhibited Th17 cell development. IL-6-mediated activation of STAT3 and in vitro Th17 cell development were all suppressed by Zn. Importantly, Zn binding changed the -helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130. Thus, we conclude that Zn suppresses STAT3 activation, which is a critical step for Th17 development.

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility