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Articles by Vishal Jain
Total Records ( 3 ) for Vishal Jain
  D.S. Rajput , Amit Alexander , Vishal Jain , T.K. Giri , D.K. Tripathi and Ajazuddin
  The oral delivery of hydrophobic drugs faces a major challenge because of the low aqueous solubility of such compounds. Approximately, 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system because of their low bioavailability. The availability of the drug for absorption can be enhanced by presentation of the drug as a solubilizer within a colloidal dispersion. Self-emulsifying Drug Delivery Systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. The principal characteristic of these systems is their ability to form fine oil-in-water (o/w) emulsions or microemulsions upon mild agitation following dilution by an aqueous phase through the gastrointestinal tract for lipophilic drugs, which display dissolution rate-limited absorption. SEDDS may be a promising strategy to improve the rate and extent of oral absorption. This article gives an overview of the recent advances in the study of SEDDS and improvement of pharmacokinetic parameters of bioactives through SEDDS.
  Amber Vyas , Sourav Kisore Das , Deependra Singh , Avinesh Sonker , Bina Gidwani , Vishal Jain and Manju Singh
  Very few drug delivery systems are potent enough to fight against cancer yet gentle enough on the body. The Nanoparticles have been successfully utilized to create a new drug delivery system for treatment of cancer. Study and application of nanoparticles is advancing rapidly within the pharmaceutical field. These nano-sized materials, e.g., “nanoparticles”, take on novel properties and functions that differ markedly from that delivery system presently available in market. The nano-size and surface improved solubility and multi-functionality of nanoparticles. This improves the quality and the biomedical applications of the nanoparticles. The skin provides a physical barrier to the harmful effects of the external environment in the body. The skin cancer appears in the upper layer of the skin. In recent years there has been an exciting increase in the prevalence of skin cancer worldwide. Non-melanoma skin cancer is the most common diagnosed cancer in the UK accounting for a quarter of all new cancer cases. It is a slow growing form of cancer and can be present many years before detection. Several obstacles frequently still encountered with the skin cancer. In general, the best way to eliminate a problem is to eliminate the cause. This article has reviewed nanoparticulate delivery system with a view as to its impact on skin cancer.
  Rakesh Tiwle , Ajazuddin , Tapan Kumar Giri , Dulal Krishna Tripathi , Vishal Jain and Amit Alexander
  The combinatorial chemistry and high throughput screening increases the solubility of poorly water soluble compounds. The most challenging task in development of a formulation is the solubility of drug, availability at the site of action and stability of drug. Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in vivo efficacy. Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. Therefore, drug release profiles are exhibited by such formulations for poorly soluble drugs to improve the solubility of such poorly soluble drugs. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Water is the solvent of choice for liquid pharmaceutical formulations. Most of drugs which are weakly acidic and basic show poor aqueous solubility hence various methods like, salt formation, co-solvency, micronization, addition of agent, solid dispersion, complexation etc., are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs. This article reviews various methods used for improving the solubility of hydrophobic drugs and improve the drug release profiles which are exhibited by such formulations for poorly soluble drugs.
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