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Articles by Vijay Kumar
Total Records ( 6 ) for Vijay Kumar
  Lokesh Kumar Bhati , Gaurav Tiwari , Ruchi Tiwari and Vijay Kumar
  Investigation on binary and ternary systems of β-cyclodextrin (β-CD) and hydroxypropyl-β cyclodextrin (HPβ-CD) with Polyvinylpyrrolidone (PVP) on the solubility of Meloxicam (MX) was studied. Phase solubility analysis with PVP K-30 v was used to investigate interactions in aqueous solution between MX and the carrier, either alone or in combination. Equimolar MX and both CDs solid systems, in the presence or the absence of 0.4% (w/w) PVP, were prepared by kneading, co-evaporation or freeze-drying and characterized by differential scanning calorimetry, X-ray powder diffraction analysis, scanning electron microscopy, infrared spectroscopy and dissolution studies. The combined use of PVP and CDs resulted in a synergistic increasing effect of the aqueous solubility of MX. The phenomenon was interpreted in terms of the strongest complexation capacity of CDs towards MX. The positive effect of PVP K30 also reflected on MX dissolution rates from solid preparations, because all ternary systems, with exception of physical mixtures, dissolved faster than the corresponding MX-CDs binary systems the results of solid state studies accounted for the occurrence of stronger interaction in ternary than in binary systems.
  Vijay Kumar , Sutapa Mukhopadhyay , Preetmohinder Singh Bedi , Gurfateh Singh and Pitchai Balakumar
  The present study has been designed to investigate the possible modulating role of vitamin D3 on chronic exercise-induced apoptosis in skeletal (gastrocnemius) muscle of rats. Rats were run for 8 weeks on a treadmill at a speed of 36 m min-1 to induce apoptosis in their skeletal muscle. Vitamin D3 (0.03 μg/100 g and 0.06 μg/100 g, s.c.) treatment, thrice weekly, was started three days prior to subjecting the animals to chronic exercise and was continued for 8 weeks of the experimental protocol. Oxidative stress was assessed by measuring the levels of TBARS, super oxide anion generation and reduced glutathione in gastrocnemius muscle. Further, serum level of corticosterone (glucocorticoid), a potent indicator of stress, was measured. Moreover, the apoptotic cell death was assessed using DNA gel electrophoresis. Chronic treadmill exercise produced profound DNA smearing. The levels of TBARS, super oxide anion generation and serum corticosterone were noted to be increased and the level of GSH was noted to be decreased in rats subjected to chronic treadmill exercise. However, treatment with vitamin D3 markedly reduced DNA smearing. Moreover, the chronic exercise-induced increases in TBARS level, superoxide anion generation and corticosterone levels were significantly attenuated by treatment with vitamin D3. In addition, vitamin D3 markedly increased the exercise-induced decrease in GSH level. It suggests that antioxidant potential of vitamin D3 and its novel efficacy in modulating exercise-induced corticosterone levels in rats may contribute to its anti-apoptotic effect.
  P.K. Singh and Vijay Kumar
  Fusarium oxysporum f. sp. chrysanthemi (FOC) is one of the most wide spread and destructive pathogen, causing infection to Chrysanthemum plants throughout the world. Qualitative evaluation of 10 FOC isolates was done for their ability to produce fusaric acid, using thin layer chromatography. A variation in FOC isolates was observed and isolate FO-1, FO-2 and FO-3 were very strong producers of fusaric acid. Isolate FO-1 produced highest biomass in liquid medium and radial diameter on solid medium and FO-2 was the slowest. Growth of FOC isolates was recorded maximum on Potato Dextrose Broth (PDB), followed by Czapex Dox Broth (CDB) and FSM-Liquid. All the isolates of FOC showed significantly (p<0.01) higher growth on pH 5 followed by 7, 9, 3 and 11. FOC isolates growth was highest at temperature of 25°C followed by 30, 20, 15, 35 and 40°C. None of FOC isolates showed radial growth at 40 and 45°C. Results of this study has revealed that a temperature of 25°C, pH of 5.0 and Potato dextrose medium was most suitable for the growth of FOC isolates.
  Neeraj Sharma , Meena Kumari , Vijay Kumar , S. C. Chaudhry and S. S. Kanwar
  Vanadium(IV) complexes of composition [VCl2-n(acac)2(HL1,2)n] (1-4) (where acac = ( CH3COCHCOCH-3)HL1 = C6H5OCH2C(O)NHO-; phenoxyacetohydroxamate ion; HL2 = C6H5CH = CHC(O)NHO-; cinnamylhydroxamate ion, n = 1 and 2 have been synthesized by reaction of [VCl2(acac)2] with the potassium salt of phenoxyacetohydroxamic and cinnamylhydroxamic acids in predetermined molar ratios in THF + MeOH. The characterization of the complexes has been accomplished by elemental analyses, molar conductivity, magnetic measurements, IR, electronic, and mass spectral studies. Based upon spectral and molecular modeling dynamics, a distorted octahedral geometry around vanadium has been proposed. The thermal behavior of the complexes has been studied by TG and DTA techniques. The antibacterial activities of the newly synthesized complexes, vanadium precursor, and ligands have been assayed by the minimum inhibitory concentration method. The complexes have improved antibacterial activity over the free ligands.
  Amit Sharma and Vijay Kumar
  In this study, researchers discuss the frequency modes (first two modes) of non-homogeneous isotropic square plate on C-C-S-S condition where C and S represent clamed and simply supported, respectively. Here, thickness varies linearly in one direction. For non homogneity in the material, we considered circular varation in density. Bi-parabolic temperature variation on the plate is also being viewed. To find the vibrational frequency, Rayleigh Ritz technique has been applied for the different values of plate’s parameters.
  Rafida Razali , Vijay Kumar and Cahyo Budiman
  Background and Objective: The MD2 pineapple contains 14 various sizes of bromelain (MD2-bromelains) ranging from 19-200 kDa which are suspected to be structurally and enzymatically varied. This study aims to compare the enzymatic activity and structural features of small and medium-sizes of MD2-bromelains, designated as MD2-SBro (19 kDa) and MD2-MBro (38 kDa), respectively. Materials and Methods: Purified recombinant MD2-SBro and MD2-MBro obtained were used in this study. The enzymatic activity of both MD2-bromelain was determined using a plate agar system with casein as a substrate. Three-dimensional (3D) structures of both MD2-bromelains were constructed under SWISS-MODEL server-based structural homology modeling and verified stereo-chemically. Results: The MD2-SBro and MD2-MBro were shown to be enzymatically active toward casein with MD2-MBro exhibited higher enzymatic activity than MD2-SBro. The 3D structures revealed that Cys-His active site position of MD2-SBro was found to be located in the inappropriate location for catalysis. Besides, the substrate-binding pocket of MD2-SBro was found to be less hydrophobic than that of MD2-MBro. Conclusion: Unique structural features around the active site of MD2-SBro and MD2-MBro might account for the discrepancy in their enzymatic activities.
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