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Articles by Vijai Lakshmi
Total Records ( 4 ) for Vijai Lakshmi
  Vijai Lakshmi and Poonam Gupta
  The article deals with the chemical constituents isolated from all the Indian species of Xylocarpus viz. X. granatum, X. moluccensis, and X. mekongensis. A total of about 70 pure compounds of different classes have been covered. The article describes the biosynthetic pathway of limonoids and sources, bioactivities and chemical and physical constants of the different classes of compounds.
  Neetu Singh , Pratibha Singh , Gautam Palit and Vijai Lakshmi
  Aim: Preliminary study revealed that gedunin and photogedunin, from Xylocarpus granatum exhibit anti-ulcer property. In an attempt to clarify the mechanism involved in its anti-ulcerogenic potential, an advanced studies to examine their effects on potent gastric acid secretagogues i.e., plasma gastrin and gastric mucosal histamine in pyloric ligation induced ulcer model. In addition, an evaluation of the cytoprotective function of these compounds by assessing the gastric PGE2 levels in alcohol induced gastric ulcer model. Methods: Adult Sprague Dawley rats, weighing 180-220 g procured from National Laboratory Animal Centre, CDRI, were used in the study. Rats were housed three to four per cage, in a room with temperature regulated at 22±2°C, with a 12 h/12 h light/dark cycle (lights on 07:00 h, lights off 19:00 h). Standard chow pellets and water were given ad libitum, except during the period when food deprivation was applied. Compounds of Xylocarpus granatum and standard drugs like omeprazole (10 mg kg-1) and sucralfate (500 mg kg-1) were prepared in 1% carboxymethyl cellulose (CMC) as suspension and administered orally 45 min prior to exposure of ulcerogens to the animals at a volume of 1 mL/200 g of body weight. All animals were deprived of food for 16 h before ulcerogens exposure and were divided into three groups, (n = 6). Control group of animals were treated with vehicle 1% CMC. Compound gedunin and photogedunin (20 mg kg-1, p.o.) were tested against alcohol and pyloric ligation induced gastric ulcer model. Standard anti-ulcer drugs, omeprazole (10 mg kg-1, p.o.) were treated in pyloric ligation model and sucralfate (500 mg kg-1, p.o.) in alcohol induced ulcer model. Results: Gedunin and photogedunin exerted significant acid lowering activity in pyloric ligated rats as evident through reduced free acidity and total acidity as well as in vitro H+K+-ATPase activity. Also, both compounds normalized the plasma gastrin and tissue histamine level compared to ulcerated rats. Contrastingly, both compounds illustrated no significant increase in gastric PGE2 level and mucin content compared to ulcer control rats. Conclusion: Thus, the study suggested that gedunin and photogedunin imparts gastro-protection through antisecretory mechanism.
  Vijai Lakshmi , Santosh Kumar Agarwal , Abbas Ali Mahdi , Vaibhav Mishra , Haushila Prasad Pandey and Gautam Palit
  Background: Currently, natural products have been shown to present interesting biological and pharmacological activities and are used as chemotherapeutic agents. Plants have historically been used in treating cancer and are recognized for their ability to produce secondary metabolites. Objective: The current study was designed to evaluate the antiulcer activity of total extract as well as several fractions from Cantharanthus roseous Linn. (Family; Apocyanaceae) leaves. The bioassay guided chloroform fraction of the ethanol extract yielded two major compounds which have shown a promising antiulcer activity. Materials and methods: C. roseus leaves were evaluated against Cold Restraint Ulcer (CRU), Aspirin (AS), Alcohol (AL) and Pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity was observed. Results: Potential anti-ulcer activity was observed against CRU (75.18%), AS (50.00%), AL (65.00%) and PL (50.00%) induced ulcer models. The standard drug omeprazole (10 mg kg-1, p.o.) showed 77.34% protection against CRU, 57.08% against AS and 69.42% against PL induced ulcer model. Sucralfate, another standard drug (500 mg kg-1, p.o.) showed 62.72% protection in AL induced ulcer model. Ethanol extract of C. roseus leaves significantly reduced free acidity (17.78%), total acidity (8.05%) and up regulated mucin secretion by 25.11%, respectively. Phytochemical investigations of chloroform fraction yielded vincamine and vindoline . Further, Fr-CHCl3 and its compounds vincamine and vindoline significantly showing protection against CRU 81.08 and 81.20%, respectively, confirming their anti-ulcer activity. Discussion and conclusion: The anti-ulcerogenic activity of the chloroform fraction might be due to its anti-secretory activity. This study is the first of its kind to show significant anti-ulcer effect of C. roseus. Therefore, it could act as a potent therapeutic agent against peptic ulcer disease.
  Ram Raghubir , Vikas Mishra , Sheeba S. Samuel and Vijai Lakshmi
  Marine biota is a rich source of biologically active molecules. Here we would like to investigate the presence of a potent neurotoxin in the parazoanthus species possessing NMDA agonistic activity. A species of green parazoanthus collected from west coast of Gujarat was assessed for presence of biologically active constituents in its extracts. The Methanolic Extract (ME) of parazoanthus was found to possess potent neurotoxic property, which on systemic administration significantly enhanced the neuro-behavioural and autonomic activity in albino mice, culminating into convulsions and even death at accelerated doses. The ME on systemic administration caused significant increase in the firing rate of cortical neurons of rats, which suggests presence of neuroexcitatory component in the ME. Moreover, receptor binding studies also revealed its affinity to glutamate receptors, which was further found to be selective for NMDA receptors, as NMDA antagonist, MK-801, significantly inhibited ME induced convulsions. These studies suggest presence of potent neurotoxic component in ME of parazooanthus species, possessing NMDA agonistic property.
 
 
 
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