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Articles by Veerasamy Sejian
Total Records ( 6 ) for Veerasamy Sejian
  Veerasamy Sejian , Jeffrey Lakritz , Thaddeus Ezeji and Rattan Lal

A CASE OF PLAGIARISM: (Case No. 07032014)

Professor Kennedy Makondo from McMaster University, Canada pointed out a plagiarism in a paper published in Asian Journal of Animal and Veterinary Advances Volume 6 Number 4, 301-315, 2011.

On the receipt of Professor Kennedy Makondo’s letter, the case forwarded to the Ethics Committee of the Science Alert. As per the report of the Ethics Committee, article entitled "Assessment Methods and Indicators of Animal Welfare" authored by Veerasamy Sejian from Division of Physiology and Biochemistry, Central Sheep and Wool Research Insitute, Avikanagar, Rajasthan-304501, India, published in Asian Journal of Animal and Veterinary Advances Volume 6 Number 4, 301-315, 2011, contains substantial sections of text that have been taken verbatim from earlier publication without clear and unambiguous attribution.

Science Alert considers misappropriation of intellectual property and duplication of text from other authors or publications without clear and unambiguous attribution totally unacceptable.

Plagiarism is a violation of copyright and a serious breach of scientific ethics. The Editors and Publisher have agreed to officially retract this article.

Science Alert is highly thankful to Professor Kennedy Makondo for pointing out this plagiarism.

Detail of article from which text has been copied by Veerasamy Sejian:

Caroline J. Hewson, Can we assess welfare? Pouvons-nous évaluer le bien-être?, VOL:44, 749-753, 2003.

  Joy Aleena , Prathap Pragna , P.R. Archana , Veerasamy Sejian , Madiajagan Bagath , Govindan Krishnan , A. Manimaran , V. Beena , E.K. Kurien , Girish Varma and Raghavendra Bhatta
  The animals possess various inherent mechanisms to cope up with the changing environmental conditions. It has been observed that the ability of the animals to adjust with these climatic extremes is related to their level of adaptation and this is inversely correlated with their production potential. In depth understanding of metabolic response of livestock adaptation might pave way for developing more viable adaptive measures to cope up livestock production system to climate change. Hence, this review is an attempt to cover the significance of metabolic response to animal adaptation during heat stress. In animals, less feed intake helps to reduce the internal heat production by minimizing the metabolic processes to adapt the heat stressed condition. Thyroid glands and thyroid hormones are mainly known to have a very important role in the thermoregulation and homeostasis of energy and protein metabolism. Further, the histological sections of the thyroid gland of livestock subjected to heat stress indicates pathological changes of less thyroglobulin in the thyroid cells reflecting a significant decrease in thyroid activity. Changes in the concentration of thyroid hormones in the blood reflect the metabolic and nutrient status of the body. Thyroid hormones play a critical role in thermogenesis and therefore are an important reflection of adaptation to heat stress in livestock species. The roles of metabolic regulators are crucial in assessing the physiological response to heat stress through various enzymes governing the metabolic reactions in blood. The decreased level of non-estrified fatty acid (NEFA) during heat stress condition in livestock is attributed to enhance the glucose burning as a presumable strategy to reduce metabolic heat production in the animal body. In addition, alteration in the levels of both aspartate aminotranspharase (AST) and alanine aminotranspharase (ALT) are correlated to adaptive potential of livestock to environmental challenges. Based on this review, it was concluded that metabolic response is one of the primary means by which the animals tries to cope up with heat stress challenges. The animal reduces their metabolic activities in an effort to reduce the metabolic heat production to cope up with outside environment heat stress condition.
  Inbaraj Sophia , Veerasamy Sejian , Madiajagan Bagath and Raghavendra Bhatta
  Background and Objective: Climate change related heat and nutritional stress weakens the animal’s immune system and makes them more prone to diseases. Although this has been observed by various researchers, the impact of these stresses on immune gene expression and process of heat stress mediated immune suppression at molecular level has not been dealt in detail in goat. Hence, the study was conducted to establish the impact of heat stress, nutritional stress and combined stresses (heat and nutritional) on different spleen Toll Like Receptor (TLR) genes expression in Osmanabadi goats. Materials and Methods: Twenty four adult Osmanabadi male goats (average body weight 16.0 kg) were divided into four groups viz., C (n = 6, control), HS (n = 6, heat stress), NS (n = 6, nutritional stress) and CS (n = 6, combined stress). The study was conducted for a period of 45 days. The C and HS goats had ad libitum access to their feed while NS and CS goats were under restricted feed (30% intake of C bucks) to induce nutritional stress. The HS and CS goats were exposed to heat stress in outside environment for 6 h a day between 10:00-16:00 h to induce heat stress. The average minimum and maximum temperature and Relative Humidity (RH) during the study period were 27.23±3.46, 38.33±0.52 and 37.0±4.16, respectively. The animals were slaughtered and their spleen was collected for different TLR mRNA expression. The relative gene expression was calculated using the formula 2–ΔΔCT. The results were expressed in fold change as compared to untreated control (control = 1 fold). Results: The fold expression level of TLR 1, 2, 3, 6, 7, 8, 9 and 10 mRNA in spleen followed the same trend in the current study where comparatively higher expression was noticed in CS group. These different TLR mRNA expressions in CS group were of higher magnitude as compared to both HS and NS group goats. This shows the severity of environmental stresses when occurring simultaneously and the consequences on immune response were much more severe than the individual stress. Conclusion: The activated splenic innate immune functions in terms of different increased TLR expression during combined stress indicate the Osmanabadi goat’s adaptation and disease resistance mechanism under extreme environmental conditions.
  Prathap Pragna , P.R. Archana , Joy Aleena , Veerasamy Sejian , Govindan Krishnan , Madiajagan Bagath , A. Manimaran , V. Beena , E.K. Kurien , Girish Varma and Raghavendra Bhatta
  Heat stress is one of the major concerns which affect the production potential of dairy cattle almost in every part of world. Elevated temperature and humidity negatively affects feed intake leading to negatively affecting the reproductive potential which ultimately decrease milk production. High yielding cows more susceptible to heat stress than the low yielders. Heat stress can increase body temperature which may affect the fat synthesis in mammary gland. Apart from reducing the milk production, heat stress can also reduce the quality of milk. Internal metabolic heat production during lactation can further reduce the resistance of cattle to high ambient temperature, resulting in altered milk composition and reduction in milk yield. Heat stress can affect the various components of milk such as fat (%), solid-non-fat, protein, casein and lactose content. Heat stress can increase the somatic cell count indicating the reduction in quality of milk produced. Further, heat stress can also cause endocrine disbalance such as altering the levels of prolactin, thyroid hormones, glucocorticoid, growth hormone, estrogen, progesterone and oxytocin which ultimately affects the milk production. Heat stress through higher udder temperature may also cause mastitis in dairy cows. In addition, heat stress during dry period in particular might trigger mammary gland involution accompanied with apoptosis and autophagy, decreased amount of mammary epithelial cells can ultimately cause decline in milk yield. It may be concluded from this review that heat stress is considered to be adversely impacting both quantity as well as quality of milk produced. Heat stress brings about these impacts through reduced feed intake, altered hormone concentration and pathological changes in udder during mastitis.
  Rajni Chhetri , T.V. Meenambigai and Veerasamy Sejian
  This review focused on our current understanding of the renal adult stem cells and their participation in kidney repair and regeneration. Currently, cells (growing in vitro) are being used as a replacement therapy/regenerative medicine with the great potential to treat kidney failure or other degenerative diseases. Regenerative medicine is now considered of great hope not only to control but also to cure some of the diseases which is otherwise difficult to treat. Recent studies have indicated that adult stem cells, either in the kidney itself or derived from the bone marrow, could participate in this repair process and might therefore be utilized clinically to treat acute renal failure. After renal ischemic injury, there is a upregulation of stromal cell-derived factor-1 expresson found in the kidney, which can induce leukocytosis and kidney repair. Renal stem cells, both from the renal papilla or the CD24+CD133+ cell niche of the Bowman’s capsule could differentiate into adult epithelial cells or tubular cells such as podocytes participate in this renal repair. Bone marrow-derived stem cells appeared to have a capacity for transdifferentiation and to be able to replace damaged renal tissue by replacing tubular epithelial cells, mesangial cells, endothelial cells and even podocytes. It is apparent from this review that there is a hidden potential within the kidney as well as in the bone marrow cells to stimulate endogenous or exogenous kidney regeneration. Further it can be speculated that harnessing the potential of these stem cells will go a long way in management and recovery of kidney failure through regenerative medicine approach.
  Veerasamy SEJIAN , Sagar SANYAL , Pradip Kr. DAS , Probal R. GHOSH , Balasubramanian SIVAKUMAR and Guru D. V. PANDIYAN
  The present study was conducted to study the influence of unilateral adrenalectomy in the black Bengal goat and to observe its influence on stress alleviation capability in terms of changes in blood chemistry, and further emphasis was given to determine whether a single gland is sufficient for survival in these animals. Six female kids were unilaterally adrenalectomised and the other 6 were maintained as intact controls. Blood samples were drawn at regular intervals before and after surgery. Parameters included in the study were blood pH, blood volume, TEC, haemoglobin, PCV, TLC, differential leukocyte count, cortisol, glucose, total cholesterol, total protein, urea, and blood urea nitrogen. All the parameters were estimated by standard methods. All the blood biochemical parameters in the present study showed significant differences (P < 0.01) when compared to intact control animals. There was a significant increase in total plasma protein, total plasma cholesterol, blood urea, and blood urea nitrogen, and a significant decrease in plasma glucose and cortisol. The present study indicated that acute changes occurred in the blood biochemical parameters on unilateral adrenalectomy of the left adrenal gland that were later compensated for by the other intact right adrenal gland.
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