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Articles by Veerappan Ramanathan
Total Records ( 2 ) for Veerappan Ramanathan
  Veerappan Ramanathan and Senthilkumar Rajagopal
  Background: It is investigated to deduct the action of chrysin on the cardiovascular risk of Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. The L-NAME is a non-specific Nitric Oxide (NO) synthase inhibitor, commonly used for the induction of NO-deficient hypertension. Materials and Methods: The L-NAME (40 mg kg–1 b.wt.) was dissolved in drinking water and was given to rats at an interval of 24 h for 8 weeks. Chrysin were administered orally once in a day in the morning for 4 weeks. The compound was suspended in 2% dimethyl sulfoxide solution and fed by incubation. After 8th week morning the animals were sacrificed by cervical dislocation and done with lipid profiles parameters. Results: Administration of L-NAME significantly increased the mean arterial pressure and heart rate compared to control rats, while treatment with chrysin significantly reduced the mean arterial pressure and heart rate compared to hypertensive rats. When L-NAME-induced hypertensive rats compared with the control, an extend sign were seen in the factors such as the concentrations of plasma, tissue (liver and kidney) lipids, lipoproteins and hepatic marker enzymes and a decrement were noted in the concentration of high-density lipoprotein cholesterol. A recent of hyperlipidemia resulted from oral prescription of chrysin. Conclusion: Thus, chrysin gives protection against hyperlipidemic and hepatic damage in rats with L-NAME induced hypertension.
  Veerappan Ramanathan and Malarvili Thekkumalai
  Background and Objectives: High fructose feeding in rats not only induces insulin resistance, but it may also induce hyperinsulinemia, hyperglycemia and dyslipidemia. Achyranthes aspera (A. aspera) exhibited potent hypolipidimic activity. This study’ investigated the effects of A. aspera on the content and characteristics of carbohydrate bound enzymes and protein bound carbohydrates of rats with high fructose fed diet (HFFD). Materials and Methods: The insulin resistance in fructose-fed rats is associated with the defects in insulin signalling pathways. Twenty four male wistar rats were randomly divided into four groups of six animals each. Normal Control group I, A. aspera supplemented control group II, A. aspera not supplemented group III and supplemented fructose-fed group IV. The estimation of carbohydrate bound enzymes and protein bound carbohydrates were studied. Statistical analysis was performed using one way analysis of variance (ANOVA) followed by Duncan’s Multiple Range Test (DMRT) using SPSS software package 19.0 (significant value p<0.05). Results: Administration of A. aspera results in significant reduction of hexokinase D, glucose-6-phosphatase (G-6-P) and fructose-1, 6-bisphosphatase (F-1, 6-P) activities, hexose, hexosamine, sialic acid and fucose in plasma. Conclusion: It was concluded that A. aspera treatment was found to be effective in improving insulin sensitivity and metabolic alterations of carbohydrate and protein associated with consumption of HFFD.
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