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Articles by Valadi Ali
Total Records ( 2 ) for Valadi Ali
  Ali M. Bahrami and Valadi Ali
  As a folk remedy, Anethum chryseum leaves is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum chryseum in mice. Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g kg-1 i.p., (1.5, 6.16) and 6.98 g kg-1, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. chryseum leaves extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.
  A.M. Bahrami and Valadi Ali
  The in vitro antibacterial activity of ethanolic leaf extract of Scrophularia striata alone and in combination with antibiotics (doxycycline and ofloxacin) by means of Fractional Inhibitory Concentration Indices (FICI) as well as by the use of time-kill assays Gram-positive bacterium (Staphylococcus aureus). Antibacterial activity was assayed by using the microdilution method. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined for the ethanolic leaf extract of Scrophularia striata alone and also in combination with antibiotics using the fractional inhibitory concentration (FIC) and time-kil assay method. Synergism was also tested using checker board dilution method. MIC/MBC values for ethanolic leaf extract of Scrophularia striata against all the tested bacteria ranged between 25.5-52.6/22.4-60.5 μg mL-1, for doxycycline 4.0/4.0-4.5 μg mL-1 and for ofloxacin 0.625-2.5/1.25-5.0 μg mL-1, respectively. The average log reduction in viable cell count in time-kill assay ranged between 2.4-4.5 log10 cfu mL-1 after 1 h of interaction and between 3.9-5.0 log10 cfu mL-1 after 3 h interaction in 1xMIC to 4xMIC. When leaf extract and antibiotics were combined, the average log reduction in viable cell count for doxycycline from 1.5-5.18 log10 cfu mL-1 and for ofloxacin 3.06-5.39 log10 cfu mL-1.
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