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Articles by Vahid Sheibani
Total Records ( 4 ) for Vahid Sheibani
  Gholamreza Sepehri , Vahid Sheibani , Afrooz Azarang , Ali Shamsizadeh , Mohammad Reza Afarinesh , Saeed Azizollahi and Ehsan Sepehri
  Problem statement: The present study was performed to determine the effect of Intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the analgesic effect and development of tolerance to antinociceptive effect of acute and chronic morphine administration respectively. Approach: This study was carried out on male wistar rats, weighing 200-250 g. For acute experimental protocol, Morphine was injected intraperitonealy in a single dose (5 mg kg-1). For chronic experimental protocol, Morphine was administered daily (15 mg kg-1 for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. In acute and chronic experiments, W-7 (0.25, 0.5 and 1 μmol/rat) was injected through ICV at different paradigms. Maximal Possible Effect percentage (MPE%) was considered as analgesia index. Results: Our result showed that W-7 (0.25, 0.5 and 1 μmol/rat) injections before acute morphine administration significantly reduced the analgesic effect of morphine compared with morphine treated group (all p<0.05). Chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 μmol/rat) decreased the development of tolerance to it. Conclusion: In conclusion these data showed that acute administration of W-7 reduced the analgesics effect of morphine and chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.
  Gholamreza Sepehri , Kayvan Yaghoobi , Vahid Sheibani , Ali Shamsizadeh and Mohammad Khaksari
  Problem statement: This study was performed to evaluate the effect of W7 (specific calmodulin inhibitor) on morphine induced analgesia in Adrenalectomized (ADX) rats by tail-flick test. Approach: Tolerance to morphine was induced in male Wistar rats by daily injections of morphine (15 mg kg-1, i.p) for 8 days. Adrenalectomy was performed under general anesthesia with intraperitoneal (i.p) injection of ketamine (50 mg kg-1) and xylazine (5 mg kg-1). In sham operated animals only the incision was made but adrenals were not removed. Five days after surgery, W7 (0.25, 0.5, 1 and 2 μmol rat-1) was injected Intracerebroventricularlly (ICV) concomitant with morphine (15 mg kg-1, i.p) for 8 consecutive days. Tail Flick Latency (TFL) was used to assess the nociceptive response at days 1, 3, 5 and 8 before and 30 min after morphine administration in sham operated and ADX rats. Maximal Possible Effect percentage (MPE %) was considered as analgesia index. Results: The results showed that daily morphine injection caused a marked analgesia in rats, but MPE % decreased significantly after 8 days which shows the development of tolerance to morphine (p<0.05). MPE % following morphine treatment in ADX rats was significantly greater than sham operated rats (p<0.05) and W7 (0.5, 1 and 2 micromol/rat/ICV) significantly attenuated the development of tolerance to morphine in ADX rats compared to sham operated rats (p<0.05 and p<0.001). Corticosterone replacement reversed the effect of W7 on ADX rats (p<0.005). Conclusion: The results of this study showed that hypothalamic- pituitary-adrenal axis and calmodulin may play a role in the development of tolerance to morphine antinociceptive effects in rats.
  Bijan Naghibi , Vahid Sheibani , Mostafa bagherinia , Gholamreza dehghan-nudeh and Fariba Sharififar
  Ghavoot is an Iranian preparation composed of a combination of different plant seeds which has been prepared in a specific manipulation. This drug has different traditional uses which has never been studied scientifically. In the present study, the anti anxiety effect of Ghavoot has been studied in mice using Elevated Zero Maze (EZM) method. The animals received the Ghavoot at doses of 12, 18 and 24 g kg-1 orally for 14 days. The anxiolytic effect of test groups was compared to diazepam on the basis of animal behaviors on 15th day of experiment. The time spent in the open arms, number of open arm entries, number of animal stretching, line crossing and deep heading of animal on open edges were measured for 5 min. All of the experiment were done at the time of 9-13 a.m. The results showed that Ghavoot significantly (p<0.05) elevated the time spent on the open arms and open arm entries at dose of 24 g kg-1 in comparison to control group, without significant changes in the other paramaters. The results here provide scientific evidence that Ghavoot has potential anti anxiety effect in mice.
  Arezoo Saberi , Gholamreza Sepehrib , Saeed Esmaeili-Mahani , Bahram Rasoulian , Vahid Sheibani , Khadije Esmaeilpour , Zahra Hajializadeh and Elham Abbasloo
  Satureja khuzistanica is used as anti-inflammatory, antinociceptive and antiseptic in folk medicine; however, its analgesic effects have not yet been clarified in different scientific models of pain. The Objective of this work was to determine the antinociceptive activity of Satureja khuzistanica and possible involvement of opioid system in several model of pain in rats. All experiments were carried out on male Wistar rats. The tail-flick, hot-plate and acid acetic tests were used to assess the antinociceptive effect of Satureja khuzistanica Extract (SKE). The extract was given at doses of 12, 25, 50 and 100 mg kg-1 intraperitoneally (i.p.). Naloxone (3 mg kg-1) was used to evaluate the opioid receptor involvement in SKE antinociceptive effects. The data showed that SKE caused a dose-dependent analgesic effect on tail-flick, hot-plate and acid acetic tests. The Maximum antinociceptive activity of Satureja extract was observed 30 min after the injection of 100 mg kg-1 and significantly persisted up to 45 min. Blockage of opioid receptors by naloxone (3 mg kg-1) could not prevent SKE-induced analgesic effect. In addition, SKE could potentiate the antinociceptive effect of 5 mg kg-1 morphine on tail-flick test. Co-administration of 12 mg kg-1 SKE with 3 mg kg-1 morphine produced potent antinociceptive effects which were greater than those in morphine-treated or SKE group (p<0.001). Our results indicate that SKE has analgesic property in several models of pain and it can be used for the treatment and/or management of painful conditions.
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