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Articles by V.O. Sekoni
Total Records ( 4 ) for V.O. Sekoni
  EOgwu , E.O. Oyedipe , K.Bawa , V.O. Sekoni , S.A.S. Olorunju , K.A.N. Esievo and D.V. Uza, D
  Three groups of pregnant Yankasa (YK) and West African Dwarf (WAD) ewes, made up of 6pregnant YK and 6 pregnant WAD ewes in each group, were assigned at random to first, second and third trimester of pregnancy, to study the clinical manifestation of. T. vivax infection at each trimester of pregnancy. A fourth group made up of 3 pregnant YK and 3 pregnant WAD ewes served as the non-infected controls for the study. Pre- infection mean rectal temperatures of the YK and WAD ewes were 38.6 Co and 38.7 Crespectively, while post-infection temperatures were as high as 41.5 C and 41.6 C for the YK and WAD ewes respectively. The infection was severe in the infected YK and WAD ewes in the second and third trimesters of pregnancy and most severe in YK than in the WAD ewes. The infected YK and WAD ewes exhibited pyrexia, signs of anaemia shown by pale mucus membrane, decrease in packed cell volume (PCV) values, decrease in total plasma protein (TP) values, weight loss, lethargy, dullness, abortions and death of ewes. The severity of the infection increased as the pregnancy advanced in the ewes. WAD ewes in the first trimester were least susceptible to the infection and self-cure was observed in one WAD ewe. The infected WAD ewes controlled the effects of the infection on abortions and mortality more than the YK ewes. It was concluded from the study that the trimester of pregnancy and breed of ewe influenced the clinical manifestation of T. vivax infection on pregnant YK and WAD ewes.
  E.K Bawa , V.O. Sekoni , D. Ogwu , K.A.N. Esievo and D.V. Uza
  The results of chemotherapy with the Trypanocidal drug Novidium, on the clinical manifestation ? of Trypanosoma vivax infected pregnant Yankasa (YK) and pregnant West African Dwarf (WAD) ewes was investigated. Three groups of pregnant YK and pregnant WAD ewes, comprising of 6 YK and 6WAD per group, were randomLy assigned to first, second and third trimesters of pregnancy and infected with T. vivax at each trimester. A fourth group comprising of 3 uninfected pregnant YK and 3 uninfected pregnant WAD ewes were the controls for the study. Two weeks post infection the infected ewes in each trimester period were divided into two equal groups of three ewes each. One group was treated with Novidium (Homidium chloride), ? at 1.0 mg kgG body weight, the other group remained untreated. Blood samples from the treated ewes were 1 negative for trypanosomes within 4 days post-chemotherapy. As the study progressed, clinical signs associated with trypanosomosis, such as anaemia indicated by low packed cell volume (PCV), loss in body weights, pyrexia and decline in total plasma protein (TP) values observed in the infected ewes, disappeared gradually following chemotherapy. Treatment had significant (p#0.05) positive effects on PCV values of the treated YK and WAD ewes in the third trimester, TP values of treated YK in the first and second trimester, body weight of treated YK ewes in the second trimester, TP values of treated WAD ewes in the first, second and third trimester and body weights of treated WAD ewes in the second and third trimesters. The trimester of pregnancy and breed of ewe influenced the results of Novidium chemotherapy on observed clinical parameters.?
  E.K. Bawa and V.O. Sekoni
  The objective of the study was to investigate the results of Novidium (Homidium chloride) (R) chemotherapy on the effects of Trypanosoma. vivax infection on pregnancy and reproduction in Yankasa (YK) and West African Dwarf (WAD) ewes, infected in their first, second and third trimester of pregnancy. Three groups of ewes, made up of six pregnant YK and six pregnant WAD ewes each, were assigned at random to first, second and third trimesters of pregnancy. A fourth group of three pregnant YK and three pregnant WAD ewes formed the controls for the study. The experimental ewes in the first, second and third trimesters of pregnancy, were infected by jugular vene-puncture with 2.0 mLof blood, containing 2x10 Trypanosoma vivax 6 on day 23, 52 and 102 of pregnancy respectively. The control ewes were not infected. Fourteen days post infection (pi), the experimental ewes in each trimester, were divided into two groups of 3 pregnant YK and 3 pregnant WAD ewes in each group. One group was treated with Novidium at 1.0 mg kgG body weight, while (R) 1 the other group remained untreated. Of the 3 YK and 3 WAD ewes in the treated and untreated groups in each trimester of pregnancy, 1 YK and 1 WAD ewe each from the second groups, were killed humanely at 21days pi and at the end of the first and second trimester of pregnancy. The results of the study showed that the infected YK and WAD ewes were susceptible to trypanosomosis. Very low foetal weights, partial and almost complete foetal resorption, abortions and mortality were observed in the infected-untreated YK ewes. While abortions of autolyzed foetuses, abortion of a live foetus and a case of dystocia were observed in the infected-treated YK ewes. Embryonic mortality and abortions were observed in the infected untreated WAD ewes, while delivery of healthy lambs and resumption of normal oestrus was observed in the infected-treated WAD ewes. The non-infected YK and WAD control ewes had normal gestation and delivery of lambs Chemotherapy completely ameliorated the pathogenic effects of T. vivax infection on pregnancy and gestation in the WAD ewes, leading to delivery of healthy lambs and resumption of normal oestrus and reproduction, in contrast to the YK ewes. The breed of ewe influenced the results of Novidium chemotherapy on the effects of T. vivax (R) infection on pregnancy and reproduction.
  S. Adamu , M.Y. Fatihu , N.M. Useh , N.D.G. Ibrahim , M. Mamman , V.O. Sekoni and K.A.N. Esievo
  In order to investigate whether testicular pathologic changes reported in trypanosome-infected animals are related to declining testosterone concentrations or not, four White Fulani bulls (infected group) with similar ages and weights were infected with Trypanosoma vivax (T. vivax), Kudaru stock, by inoculating each, intravenously, with 2 mL of blood from an infected donor calf containing 2106 T. vivax organisms. Three other White Fulani bulls, with ages and weights similar to those of the infected group, which were uninfected, served as control group. Blood samples were collected from animals in the two groups before and after the infection to determine Packed Cell Volume (PCV) and serum testosterone profile. To carry out histopathological studies on the testes and other organs in the body of these animals, one bull from the infected group was sacrificed on day 14 Post-Infection (PI), while two bulls (one each from the infected and control groups) were sacrificed, each, on days 28, 56 and 84 PI. All animals in the infected group were parasitaemic by day 6 PI. This was followed by a gradual and progressive decrease in the values of Packed Cell Volume (PCV) and serum testosterone concentrations in these animals. PI values of these parameters in the control group remained normal relative to the pre-infection ones. The mean PI testosterone concentrations, measured in ng mL 1, in individual bulls of the infected group sacrificed on days 14, 28, 56 and 84 were 9.6±4.2, 7.8±3.7, 4.9±4.1 and 5.0±3.4, respectively. Histopathologically, severe testicular degeneration was observed in all animals in the infected group characterized by necrosis and depletion of the spermatogenic and sertoli cells in the seminiferous tubules. Leydig cells in the interstitial tissues of the testes were also severely degenerated. Severity of the lesions was related to serum testosterone concentrations as testicular degeneration was progressive from the bull that was sacrificed on day 14 PI moving through to the bull that was sacrificed on day 56 PI which had the least mean PI testosterone concentration and in which both spermatogenic and sertoli cells had undergone karyolysis and so were completely depleted. In contrast, testes of bulls in the control group were normal as both seminiferous tubules and interstitial tissues of the testes contained full complement of the spermatogenic and Leydig cells, respectively. It is concluded from this study that lowering testosterone concentration may be an aggravating factor to the degenerative changes observed in the testes of trypanosome-infected male animals.
 
 
 
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